Figure 5. Schematic view of the correlation between the modes of engraftment with the type of relapse.

In engraftment mode A, both the clonal composition (all clonal mutations with AF > 30%) and the clonal architecture are captured in the corresponding PDX. In mode B, the composition of the major clone including its characteristic SNVs and CNAs and/or the clonal architecture is remodeled in the PDX by clonal selection; gray—core mutations common for both initial diagnosis and relapse; blue—mutations specific to initial diagnosis; red—relapse‐specific mutations.