Table 7.
Detection of p24 antigen by the 4th generation RSTs/STs.
| Group | Subtype | Final concentration (pg/mL)a | BioTechMed HIV1/2 Rapid-4 |
HIV combo |
||
|---|---|---|---|---|---|---|
| T1 | T2 | Ag | Ab | |||
| HIV-1/M | B | 145 | − | − | + | − |
| HIV-1/M | CRF01_AE | 147 | − | − | + | − |
| HIV-1/M | CRF02_AG | 145.5 | − | − | + | − |
| HIV-1/M | A | 144 | − | − | + | − |
| HIV-1/M | C | 134.5 | − | − | + | − |
| HIV-1/M | D | 137.5 | − | − | + | − |
| HIV-1/M | H | 130 | − | − | + | − |
| HIV-1/M | cpx | 149 | − | − | − | − |
| HIV-1/O | H | 153.6 | − | − | + | − |
| HIV-1/N | NA | 100 | − | − | + | − |
| HIV-1/P | NA | 149.8 | − | − | − | − |
| HIV-2 | B | ND | − | − | − | − |
The performance of the two 4G tests to detect p24Ag only was evaluated on a panel of 12 reconstituted whole blood samples loaded with HIV culture supernatant. The p24 concentrations mimic the physiopathological in vivo concentration during PHI.
a
After reconstitution of whole blood.