Table 1.
Number of cells expressing IL-20 related cytokines and their receptors in peribronchial area from lung sections.
| IL-19 | IL-20 | IL-24 | IL-20Ra | IL-20Rb | IL-22Ra | |
|---|---|---|---|---|---|---|
| PBS | 24.8 ± 2.3 | 9.6 ± 1.6 | 13.9 ± 1.5 | 70.6 ± 5.2 | 33.2 ± 11.9 | 31.4 ± 4.8 |
| Sp | 84.4 ± 1.0 | 55.4 ± 5.9 | 64.5 ± 28.2 | 85.3 ± 2.3 | 51.9 ± 3.2 | 85.3 ± 2.3 |
|
Sp + anti-IL20Rb |
62.9 ± 5.3 | 32.9 ± 5.5 | 56.5 ± 3.2 | 42.8 ± 9.8 | 25.3 ± 7.9 | 15.6 ± 2.1 |
Immunohistological staining of IL-20 related cytokines (IL-19, IL-20, and IL-24) and their receptors (IL-20Ra, IL-20Rb, IL-22Ra) were performed on lung tissues of PBS -, Sp – infected mice and Sp - infected mice treated with the anti-IL-20Rb neutralizing antibody. Bronchial epithelial cells were not included in the count since most of them are positive particularly for IL-19 and IL-20Ra. The results are expressed as the mean number per mm2 of positive cells in 3 to 5 fields with standard deviation.