ELISA and IHC analysis of SETD7 in serum and tissues, respectively. (A) SETD7 expression in the serum of different groups. (B-D) SETD7 expression in para-carcinoma, colorectal polyps and CRC tissue, respectively. (E) Positive expression area of SETD7 in para-carcinoma, colorectal polyps and CRC tissue. (*** indicates P < .001, ** indicates P < .01, * indicates P < .05). (F, G) SETD7 expression in T1 and T3 stage, respectively. (H, I) SETD7 expression in MSS/MSI-L and MSI-H, respectively (figures are magnified ×200, and the upper right corner is magnified ×400).