Comparative analysis of serum proteomic profiles among different groups. (A) Overall sum of the spectra (mass range from 1 to 10 kDa) of healthy controls (green) and CRC patients (red). (B) Bivariate plot of healthy controls and CRC patients with the most differentiated two peaks (m/z: 4685, 2676). (C) 3D plot of healthy controls and CRC patients.(D) Overall sum of the spectra of healthy controls (green), pre-operative (red), and post-operative CRC patients (blue). (E) Bivariate plot of healthy controls, pre-operative and post-operative CRC patients (m/z:1781, 2676). (F) 3D plot of healthy controls, pre-operative and post-operative CRC patients. (G) Overall sum of the spectra of healthy controls (green), pre-operative (red), post-operative CRC patients (blue) and patients with colorectal polyps (yellow). (H) Bivariate plot of healthy controls, pre-operative, post-operative CRC patients and patients with colorectal polyps (m/z: 4793, 2676). (I) 3D plot of healthy controls, pre-operative, post-operative CRC patients and individuals with colorectal polyps.