Fig. 4.

Reduced urate in UOx Tg mice is not associated with BP changes. (a) HPLC analysis of serum urate levels in UOx Tg and WT mice. (b) Invasive SBP versus serum urate of UOx Tg and WT mice at baseline (WT: r²=0·091, p=0·46; Tg: r²=0·046, p=0·60, pooled: r²=0·113, p=0·20). (c) Invasive SBP and HR (d) measurement before (baseline) and after vehicle and 3·3 μg/kg NOC-9 administration. n=8 and 8, UOx Tg and littermate WT mice, all male, average four-month old. (e) Noninvasive SBP and DBP measurement at the baseline (BL), during three weeks of high salt diet, low salt diet, and two weeks of washout, and pre-, post (15 min) each L-NAME administration. n=9 and 13, UOx Tg and littermate WT mice, all male, average ten-month old at the baseline. Asterisks for significant change comparing preceding time point from different treatment are above the plot for WT and below the plot for Tg. *p<0·05, **p<0·01, ***p<0·001.