Fig. 2.

Summary of interactions among TLR SNPs, CSF cytokine concentrations and clinical severity.

(a) Two cycles represent CSF cytokines associated with TLR SNPs and severity, respectively. The intersection indicates that 12 cytokines are related to both. (b) Three cycles represent TLR SNPs associated with CM susceptibility, CSF cytokine concentrations and clinical severity, respectively. Their intersections show that rs3804099 is correlated to all. CM = cryptococcal meningitis. TLR = Toll-like receptor. SNP = single nucleotide polymorphism. CSF = cerebrospinal fluid. IL = interleukin. IFN = interferon. MIP = macrophage inflammatory protein. MCP = monocyte chemo attractant protein. TNF = tumor necrosis factor. G-CSF = granulocyte-colony stimulating factor. GM-CSF = granulocyte-macrophage colony-stimulating factor. IP = interferon-induced protein. PDGF = platelet-derived growth factor. VEGF = vascular endothelial growth factor.