Table 1.
Allele and genotype distributions of 8 TLR SNPs associated with non-HIV CM in the discovery stage.
| SNP | Position | Gene | Genotype | Control |
All patients |
Immunocompetent patients |
All patients vs control |
Immunocompetent patients vs control |
||
|---|---|---|---|---|---|---|---|---|---|---|
| (n = 464) | (n = 159) | (n = 85) | OR (95% CI) | p value | OR (95% CI) | p value | ||||
| rs5743563 | 4:38804398 | TLR1 | T/T (Dominant) | 112 (24·1) | 55 (34·6) | 25 (29·4) | 1·66 (1·13–2·46) | 0·010 | 1·31 (0·78–2·19) | 0·302 |
| C/T (Over-dominant) | 248 (53·5) | 74 (46·5) | 43 (50·6) | 0·76 (0·53–1·09) | 0·133 | 0·89 (0·56–1·42) | 0·627 | |||
| C/C (Recessive) | 104 (22·4) | 30 (18·9) | 17 (20·0) | 0·81 (0·51–1·27) | 0·348 | 0·87 (0·49–1·54) | 0·622 | |||
| T (Allelic) | 472 (50·9) | 184 (57·9) | 93 (54·7) | 1·33 (1·03–1·72) | 0·031 | 1·17 (0·84–1·62) | 0·357 | |||
| rs5743604 | 4:38799664 | TLR1 | C/C (Dominant) | 142 (30·6) | 37 (23·3) | 19 (22·4) | 0·69 (0·45–1·04) | 0·078 | 0·65 (0·38–1·13) | 0·125 |
| C/T (Over-dominant) | 222 (47·8) | 75 (47·2) | 42 (49·4) | 0·97 (0·68–1·40) | 0·883 | 1·06 (0·67–1·69) | 0·790 | |||
| T/T (Recessive) | 100 (21·6) | 47 (29·6) | 24 (28·2) | 1·53 (1·02–2·29) | 0·040 | 1·43 (0·85–2·41) | 0·175 | |||
| C (Allelic) | 506 (54·5) | 149 (46·9) | 80 (47·1) | 0·74 (0·57–0·95) | 0·018 | 0·74 (0·53–1·03) | 0·073 | |||
| rs3804099 | 4:153703504 | TLR2 | T/T (Dominant) | 192 (41·4) | 81 (50·9) | 46 (54·1) | 1·47 (1·02–2·11) | 0·036 | 1·67 (1·05–2·66) | 0·029 |
| C/T (Over-dominant) | 226 (48·7) | 65 (40·9) | 32 (37·6) | 0·73 (0·51–1·05) | 0·088 | 0·64 (0·40–1·02) | 0·060 | |||
| C/C (Recessive) | 46 (9·9) | 13 (8·2) | 7 (8·2) | 0·81 (0·43–1·54) | 0·518 | 0·82 (0·36–1·87) | 0·630 | |||
| T (Allelic) | 610 (65·7) | 227 (71·4) | 124 (72·9) | 1·30 (0·98–1·72) | 0·064 | 1·41 (0·98–2·02) | 0·066 | |||
| rs1927907 | 9:117710486 | TLR4 | G/G (Dominant) | 259 (55·8) | 99 (62·3) | 53 (62·4) | 1·31 (0·90–1·89) | 0·156 | 1·31 (0·82–2·11) | 0·264 |
| G/A (Over-dominant) | 171 (36·9) | 44 (27·7) | 23 (27·1) | 0·66 (0·44–0·97) | 0·036 | 0·64 (0·38–1·06) | 0·082 | |||
| A/A (Recessive) | 34 (7·3) | 16 (10·1) | 9 (10·6) | 1·42 (0·76–2·64) | 0·273 | 1·50 (0·69–3·25) | 0·304 | |||
| G (Allelic) | 689 (74·2) | 242 (76·1) | 129 (75·9) | 1·11 (0·82–1·49) | 0·511 | 1·09 (0·75–1·60) | 0·653 | |||
| rs3796508 | 4:38828495 | TLR6 | G/G (Dominant) | 424 (91·4) | 136 (85·5) | 72 (84·7) | 0·56 (0·32–0·97) | 0·035 | 0·52 (0·27–1·03) | 0·055 |
| G/A (Over-dominant) | 40 (8·6) | 23 (14·5) | 13 (15·3) | 1·79 (1·04–3·10) | 0·035 | 1·91 (0·98–3·75) | 0·055 | |||
| G (Allelic) | 888 (95·7) | 295 (92·8) | 157 (92·4) | 0·58 (0·34–0·98) | 0·040 | 0·54 (0·28–1·04) | 0·062 | |||
| rs5743794 | 4:38831106 | TLR6 | G/G (Dominant) | 157 (33·8) | 60 (37·7) | 30 (35·3) | 1·19 (0·82–1·72) | 0·373 | 1·07 (0·66–1·73) | 0·794 |
| G/A (Over-dominant) | 226 (48·7) | 82 (51·6) | 44 (51·8) | 1·12 (0·78–1·61) | 0·533 | 1·13 (0·71–1·80) | 0·604 | |||
| A/A (Recessive) | 81 (17·5) | 17 (10·7) | 11 (12·9) | 0·57 (0·32–0·99) | 0·043 | 0·70 (0·36–1·38) | 0·305 | |||
| G (Allelic) | 540 (58·2) | 202 (63·5) | 104 (61·2) | 1·25 (0·96–1·63) | 0·095 | 1·13 (0·81–1·58) | 0·467 | |||
| rs164637 | 3:52231199 | TLR9 | C/C (Dominant) | 463 (99·8) | 154 (96·9) | 82 (96·5) | 0·07 (0·01–0·57) | 0·005 | 0·06 (0·01–0·57) | 0·013 |
| C/T (Over-dominant) | 1 (0·2) | 5 (3·1) | 3 (3·5) | 15·03 (1·74–129·67) | 0·005 | 16·94 (1·74–164·83) | 0·013 | |||
| C (Allelic) | 927 (99·9) | 313 (98·4) | 167 (98·2) | 0·07 (0·01–0·58) | 0·005 | 0·06 (0·01–0·58) | 0·013 | |||
| rs352140 | 3:52222681 | TLR9 | C/C (Dominant) | 184 (39·7) | 68 (42·8) | 44 (51·8) | 1·13 (0·79–1·64) | 0·490 | 1·63 (1·03–2·60) | 0·037 |
| C/T (Over-dominant) | 224 (48·3) | 61 (38·4) | 28 (32·9) | 0·67 (0·46–0·96) | 0·030 | 0·53 (0·32–0·86) | 0·009 | |||
| T/T (Recessive) | 56 (12·1) | 30 (18·9) | 13 (15·3) | 1·69 (1·04–2·75) | 0·032 | 1·32 (0·68–2·53) | 0·410 | |||
| C (Allelic) | 592 (63·2) | 197 (61·9) | 116 (68·2) | 0·95 (0·73–1·23) | 0·679 | 1·22 (0·86–1·73) | 0·266 | |||
Data are n (%). TLR = Toll-like receptor. SNP = single nucleotide polymorphism. HIV = human immunodeficiency virus. CM = cryptococcal meningitis.