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. 2018 Dec 4;10:6641–6647. doi: 10.2147/CMAR.S183043

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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MFT promotes the proliferation and invasion of ovarian cancer cells.

Notes: The MTT results showed that supernatants of fibrotic HMrSV5 cell (Fibro-HM) stimulated the proliferation of ovarian cancer cells. (A) SKOV3 and (B) HO8910; results are represented as mean ± SD of three experiments. *P<0.01. Cell migration was monitored using a Transwell chamber assay. The SKOV3 was seeded into the upper chamber. The cells were induced with medium from the lower chamber to migrate without FBS for 20 h and then replaced with (C) HMrSV5 cell suspension in serum-free medium, (D) HMrSV5 cell suspension in SKOV3 medium, (E) HMrSV5 cell suspension in serum-free medium +100 ng/mL of TGF-β1. (F) The number of migrated cancer cells was significantly increased in MFT models (D and E) compared with controls. Magnification ×200.

Abbreviation: MFT, mesothelial cell fibroblast transformation.