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. 2018 Dec 4;12:4117–4127. doi: 10.2147/DDDT.S179227

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© 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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NACA attenuated MDA level and enhanced the activity of SOD and GPx after TBI.

Notes: (A) Both the TBI (P<0.001) and TBI+ vehicle (P<0.001) groups had a higher level of MDA than the sham group. However, NACA treatment significantly suppressed TBI-induced MDA production (P<0.05). (B–C) Activities of SOD and GPx were significantly lower in the TBI and TBI+vehicle groups as compared with the sham group (all P<0.001). However, NACA significantly promoted the SOD and GPx activities when compared with the vehicle-treated group (both P<0.001); n=6 per group. ***P<0.001 vs sham group; ^#P<0.05, ^###P<0.001 vs TBI+vehicle group.

Abbreviations: GPx, glutathione peroxidase; MDA, malondialdehyde; NACA, N-acetylcysteine amide; SOD, superoxide dismutase; TBI, traumatic brain injury.