Table 2.
Univariate and multivariate Cox regression analyses estimating the risk factors for OS of IA NSCLC
| Characteristics | Univariate
|
Multivariate
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
|
| ||||||
| Sex | <0.001 | <0.001 | ||||
| Male | Ref | Ref | ||||
| Female | 0.671 | 0.618–0.741 | <0.001 | 0.693 | 0.630–0.762 | <0.001 |
| Age (years) | <0.001 | <0.001 | ||||
| <60 | Ref | Ref | ||||
| 60–75 | 1.505 | 1.298–1.746 | <0.001 | 1.434 | 1.235–1.665 | <0.001 |
| >75 | 2.470 | 2.121–2.876 | <0.001 | 2.285 | 1.955–2.672 | <0.001 |
| Race | 0.015 | 0.043 | ||||
| White | Ref | Ref | ||||
| Black | 0.899 | 0.759–1.064 | 0.215 | 0.948 | 0.799–1.126 | 0.545 |
| Others | 0.721 | 0.568–0.916 | 0.007 | 0.739 | 0.581–0.940 | 0.014 |
| Marital status | 0.040 | 0.009 | ||||
| Married | Ref | Ref | ||||
| Divorced | 1.093 | 0.952–1.255 | 0.205 | 1.229 | 1.068–1.414 | 0.004 |
| Others | 1.134 | 1.026–1.253 | 0.014 | 1.107 | 0.996–1.230 | 0.060 |
| Lobe | 0.185 | NS | ||||
| Upper | Ref | NS | ||||
| Middle | 0.825 | 0.645–1.055 | 0.126 | NS | NS | NS |
| Lower | 0.941 | 0.852–1.040 | 0.231 | NS | NS | NS |
| Pathology | <0.001 | 0.004 | ||||
| AC | Ref | Ref | ||||
| SC | 1.623 | 1.473–1.787 | <0.001 | 1.189 | 1.072–1.318 | 0.001 |
| Others | 1.208 | 1.035–1.409 | 0.016 | 1.145 | 0.970–1.352 | 0.109 |
| Differentiation | <0.001 | <0.001 | ||||
| I | Ref | Ref | ||||
| II | 1.910 | 1.660–2.197 | <0.001 | 1.874 | 1.536–2.285 | <0.001 |
| III | 2.383 | 2.064–2.751 | <0.001 | 2.242 | 1.817–2.765 | <0.001 |
| IV | 1.807 | 1.323–2.468 | <0.001 | 1.703 | 1.087–2.668 | 0.020 |
| Size (cm) | <0.001 | <0.001 | ||||
| <1.0 | Ref | Ref | ||||
| 1.0–2.0 | 1.463 | 1.267–1.688 | <0.001 | 1.297 | 1.123–1.498 | <0.001 |
| >2.0 | 2.098 | 1.802–2.444 | <0.001 | 1.728 | 1.480–2.017 | <0.001 |
| Surgery | 0.005 | 0.001 | ||||
| W | Ref | Ref | ||||
| S | 0.847 | 0.754–0.951 | 0.005 | 0.826 | 0.734–0.928 | 0.001 |
Note: Not significant (NS), P-value >0.05.
Abbreviations: AC, adenocarcinoma; LCSS, lung cancer-specific survival; NSCLC, non-small-cell lung cancer; OS, overall survival; Ref, reference; S, segmentectomy; SC, squamous cell carcinoma; W, wedge resection.