Table 3.
Univariate and multivariate Cox regression analyses estimating the risk factors for LCSS of IA NSCLC
| Characteristics | Univariate
|
Multivariate
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Sex | <0.001 | <0.001 | ||||
| Male | Ref | Ref | ||||
| Female | 0.721 | 0.638–0.814 | <0.001 | 0.761 | 0.670–0.865 | <0.001 |
| Age (years) | <0.001 | <0.001 | ||||
| <60 | Ref | Ref | ||||
| 60–75 | 1.281 | 1.063–1.542 | 0.009 | 1.237 | 1.026–1.493 | 0.026 |
| >75 | 1.858 | 1.530–2.257 | <0.001 | 1.792 | 1.466–2.189 | <0.001 |
| Race | 0.040 | 0.056 | ||||
| White | Ref | Ref | ||||
| Black | 1.012 | 0.815–1.257 | 0.911 | 1.052 | 0.844–1.312 | 0.650 |
| Others | 0.645 | 0.458–0.909 | 0.012 | 0.665 | 0.471–0.937 | 0.020 |
| Marital status | 0.223 | NS | ||||
| Married | Ref | NS | ||||
| Divorced | 1.166 | 0.975–1.394 | 0.092 | NS | NS | NS |
| Others | 1.005 | 0.876–1.154 | 0.939 | NS | NS | NS |
| Lobe | 0.652 | NS | ||||
| Upper | Ref | NS | ||||
| Middle | 0.863 | 0.620–1.201 | 0.382 | NS | NS | NS |
| Lower | 1.013 | 0.887–1.156 | 0.852 | NS | NS | NS |
| Pathology | <0.001 | 0.733 | ||||
| AC | Ref | Ref | ||||
| SC | 1.419 | 1.243–1.619 | <0.001 | 1.044 | 0.907–1.201 | 0.551 |
| Others | 1.179 | 0.960–1.448 | 0.115 | 1.077 | 0.864–1.342 | 0.510 |
| Differentiation | <0.001 | <0.001 | ||||
| I | Ref | Ref | ||||
| II | 2.048 | 1.688–2.484 | <0.001 | 1.874 | 1.536–2.285 | <0.001 |
| III | 2.545 | 2.088–3.102 | <0.001 | 2.242 | 1.817–2.765 | <0.001 |
| IV | 1.994 | 1.308–3.038 | 0.001 | 1.703 | 1.087–2.668 | 0.020 |
| Size (cm) | <0.001 | <0.001 | ||||
| <1.0 | Ref | Ref | ||||
| 1.0–2.0 | 1.400 | 1.157–1.695 | 0.001 | 1.265 | 1.043–1.534 | 0.017 |
| >2.0 | 2.054 | 1.676–2.516 | <0.001 | 1.736 | 1.412–2.133 | <0.001 |
| Surgery | 0.035 | 0.011 | ||||
| W | Ref | Ref | ||||
| S | 0.845 | 0.722–0.988 | 0.035 | 0.813 | 0.694–0.953 | 0.011 |
Note: Not significant (NS), P-value >0.05.
Abbreviations: AC, adenocarcinoma; LCSS, lung cancer-specific survival; NSCLC, non-small-cell lung cancer; OS, overall survival; Ref, reference; S, segmentectomy; SC, squamous cell carcinoma; W, wedge resection.