Supplementary Fig. 2.

Time-lapse hypoxia analysis. A) The graph shows the hypoxia profile at different time-points across the lumen. A hypoxia-induced fluorescence was observed 30 min after injecting the hypoxia-sensing dye and increased during the experiment. B) The table shows the hypoxia-induced fluorescence intensity values at different time points. To obtain these values, a section spanning from 450 μm to 750 μm (denoted by black triangles) was defined and the average intensity value was calculated. These values were used to fit the parameters used in the computational model.