. 2018 Aug 2;219(1):121–132. doi: 10.1093/infdis/jiy459

Table 4.

Multivariable Models to Predict Illness Severity in Mice Challenged with Escherichia coli Isolates

E. coli Set	UPEC_HM/ExPEC_JJ Considered?^a	Method^b	Model No.	Adjusted r²	Variable^c	β	P ^d
Total (n = 292)	No or yes^e	Forced	NA^f	.39	fyuA	0.35	<.001
					K1	0.21	<.001
					kpsM II	0.11	.10
					papAH	0.06	.26
					usp	0.06	.40
					Group B1	0.003	.96
		Stepwise	1	.33	fyuA	0.58	<.001
			2	.38	fyuA	0.49	<.001
					K1	0.24	<.001
			3	.39	fyuA	0.40	<.001
					K1	0.21	<.001
					kpsM II	0.15	.02
Fecal (n = 116)	No	Forced	NA^f	.46	K1	0.33	.002
					fyuA	0.30	.01
					malX	0.13	.20
					papAH	–0.11	.26
					clbN	0.10	.36
					iroN	0.06	.46
					kpsM II	0.06	.61
					Group B1	–0.02	.79
					STc95	–0.01	.90
		Stepwise	1	.39	fyuA	0.63	<.001
			2	.46	fyuA	0.47	<.001
					K1	0.32	<.001
	Yes	Forced	NA^f	.48	K1	0.33	.003
					UPEC_HM	0.28	.01
					ExPEC_JJ	0.22	.08
					papAH	–0.16	.14
					malX	0.10	.32
					iroN	0.07	.42
					vat	0.03	.81
					Group B1	–0.006	.95
					STc95	–0.002	.98
		Stepwise	1	.39	UPEC_HM	0.63	<.001
			2	.47	UPEC_HM	0.47	<.001
					K1	0.34	<.001
			3	.49	UPEC_HM	0.35	.001
					K1	0.32	<.001
					ExPEC_JJ	0.19	.05^d
Clinical (n = 176)	No or yes ^a	Forced	NA^f	.32	fyuA	0.29	.002
					K1	0.17	.01
					kpsM II	0.17	.06
					papEF	0.13	.10
					Group B2	0.01	.89
		Step	1	.26	fyuA	0.51	<.001
			2	.30	fyuA	0.35	<.001
					kpsM II	0.26	.002
			3	.31	fyuA	0.34	<.001
					kpsM II	0.21	.01
					K1	0.16	.02

Abbreviations: ExPEC_JJ, extraintestinal pathogenic E. coli, as defined using James Johnson’s molecular definition; NA, not applicable; UPEC_HM, uropathogenic E. coli, as defined using Harry Mobley’s molecular definition.

^aThe analysis was done with and without considering UPEC_HM and ExPEC_JJ as candidate predictor variables.

^bForced variable entry or conditional stepwise variable entry. Forward and backward stepwise entry gave identical final models; for brevity, only the stepwise forward entry models are shown.

^cDefinitions are specified in Tables 2 and 3.

^dValues <.05 are considered statistically significant. Bootstrapping findings supported all significant P values except that for ExPEC (with fecal isolates, UPEC_HM/ExPEC_JJ were considered in a stepwise model).

^eResults were the same regardless of whether UPEC_HM and ExPEC_JJ were considered, since they did not qualify as predictor variables.

^fFor forced entry, there was only 1 model per data set and variable list.