Table 3.
Effects of rbm-5 mutations on the recognition of SS altered by uaf-1(n4588).
| SS recognition in different mutants |
|||||||
|---|---|---|---|---|---|---|---|
| Gene | Splice sites | Sequence | rbm-5(n5119) | rbm-5(n5132) | uaf-1(n4588) | rbm-5(n5119); uaf-1(n4588) | rbm-5(n5132); uaf-1(n4588) |
| Alt 3ʹ SS gtag | |||||||
| mbk-2 | 3ʹ SS | cttgtag | WT | WT | Up | Suppressed | Suppressed |
| abt-5 | 3ʹ SS | attgtag | WT | WT | Down | Suppressed | Suppressed |
| papl-1 | 3ʹ SS | tttgtag | WT | WT | Down | Suppressed | Suppressed |
| F13E6.2 | 3ʹ SS | tttgtag | WT | WT | Down | Suppressed | Suppressed |
| gcy-11 | 3ʹ SS | tttgtag | WT | WT | Down | Suppressed | Suppressed |
| T26H5.8 | 3ʹ SS | attgtag | WT | WT | Down | No effect | No effect |
| Y47H9C.1 | 3ʹ SS | attgtag | WT | WT | Up | No effect | No effect |
| pgp-8 | 3ʹ SS | tttgtag | WT | WT | Down | Enhanced | Enhanced |
| Alt 3ʹ SS ttag | |||||||
| flp-1 | 3ʹ SS | cttttag | WT | WT | Up | No effect | No effect |
| str-47 | 3ʹ SS | aatttag | WT | WT | Down | No effect | No effect |
| T09F5.20 | 3ʹ SS | aatttag | WT | WT | WT | Synthetic (Down) | Synthetic (Down) |
| Alt 5ʹ SS | |||||||
| zipt-2.4 | 5ʹ SS | ATgtactgc | WT | WT | Up | Suppressed | Suppressed |