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. 2018 Oct 26;15(10):1376–1383. doi: 10.1080/15476286.2018.1534526

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Structural analyses of preQ₁ riboswitches. A) H-bond interactions between preQ₁ and RNA binding pocket of class-I riboswitch; B) H-bond interactions between preQ₁ and RNA binding pocket of class-II riboswitch; C) Three-dimensional structure of the Thermoanaerobacter tengcongensis (Tte) class-I preQ₁ riboswitch (PDB ID: 3Q50); D) Three-dimensional structure of the Lactobacillus rhamnosus class-II preQ₁ riboswitch (PDB ID: 4JF2); E) ‘Add-on’ functionalities of preQ₁ ligands with the potential to interact with phosphate backbone units at the entrance of the ligand pocket to support ligand-RNA binding.