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a) Cartoons of a normal Fab and an EFab, which has the CL and CH1 domains replaced by the two CH2 domains of IgE b) Sequence alignments of human IgG1 CH1 (including hinge in bold), kappa constant, IgE CH2 and EFab constant domains. IgG elbow sequences used in the EFab are underlined. IMGT constant domain numbering is shown above. The N-linked glycosylation site of IgE CH2 is mutated to Gln in EFabs (red).
