Table 1.

List of descriptors investigated in this study.

No.	Descriptor Name	Explanation	Source	In Final Model?
1	NoverlResa	Number of overlaps between atoms of Met residue with spatial neighbors	Structure	Yes
2	TotSasaResa	Total solvent accessible surface area of Met residue	Structure	Yes
3	anmFluca	Mean square fluctuation of Met Cα atom based on Anisotropic Network Model	Dynamics	Yes
4	hnmFluca	Mean square fluctuation of Met Cα atom based on Hinsen’s Network Model	Dynamics	Yes
5	PhobSasaResa	Hydrophobic partition of the solvent accessible surface area of Met residue	Structure	No
6	PhilSasaResa	Hydrophilic partition of the solvent accessible surface area of Met residue	Structure	No
7	cdrLength	Length of CDR in which Met is located	Sequence	No
8	Centeredness	Location of Met with respect to center of CDR	Sequence	No
9	cdrLocation	CDR in which Met is located (CDR-H1/H2/H3/L1/L2/L3)	Sequence	No
10	IgGType	IgG type of the antibody	Sequence	No
11	lcFramework	Germline family of the light chain	Sequence	No
12	hcFramework	Germline family of the heavy chain	Sequence	No
13	QSasaResa	Ratio of exposed-to-total solvent accessible surface area of Met residue	Structure	No
14	dipoleMoment	Magnitude of the dipole Moment of the mAb	Structure	No
15	energyInt	Energy of interaction between VH and VL	Structure	No
16	protpI3D	3D structure-based pI of the protein	Structure	No
17	chargeAtpH5	Net charge of the mAb at pH 5.0	Structure	No
18	chargeAtpH7	Net charge of the mAb at pH 7.0	Structure	No

^aThese descriptors were also calculated for the (N-1) ^th and (N + 1)^th residues; but not identified to be useful; where N is the index of the Met residue.