Figure 2. a, b.

(a) Histological grading of liver allografts using the Banff scheme revealed significant differences in the rejection activity index (RAI) scores among the MSC-untreated, MSC-treated, and control mice (*p<0.05). The MSC-untreated mice (Group A) were associated with a higher score (*p<0.05, Group A versus Group B, Group C, and Group D). (b) The MSC-untreated mice showed parenchymal necrosis, severe endotheliitis, and destruction of the bile ducts. The MSC-treated and control mice had virtually normal histology. The MSC-untreated mice were characterized by a prominent portal infiltrate with varying degrees of endotheliitis and bile duct inflammation.