Table 3.

The frequencies of the genotypes and alleles at TLR2 SNP rs4986790 in H. pylori-infected subjects according to the CagA status of bacteria

		TLR2 gene polymorphism				Alleles
Groups	CagA status	TT	CT	CC	Total	C	T	p
PU	CagA+	27 (38.6%)	34 (48.6%)	9 (12.9%)	70 (100.0%)	52 (37.1%)	88 (62.9%)	*0.22
	CagA-	7 (23.3%)	16 (53.3%)	7 (23.3%)	30 (100.0%)	30 (50.0%)	30 (50.0%)	**0.09
	Total	34 (34.0%)	50 (50.0%)	16 (16.0%)	100 (100.0%)	82 (41.0%)	118 (59.0%)
AS	CagA+	24 (31.6%)	40 (52.6%)	12 (15.8%)	76 (100.0%)	64 (42.1%)	88 (57.9%)	*0.03
	CagA-	26 (52.6%)	15 (30.6%)	8 (16.3%)	49 (100.0%)	31 (31.6%)	67 (68.4%)	**0.09
	Total	50 (40.0%)	55 (44.0%)	20 (16.0%)	125 (100.0%)	95 (38.0%)	155 (62.0%)
NHS	----	56 (44.8%)	39 (31.2%)	30 (24.0%)	125 (100.0%)	99 (39.6%)	151	(0.4%)

^{*, **}comparison of the genotypes and alleles distribution at SNP rs4986790 between subjects infected with CagA+ strains of H. pylori and those infected with CagA- strains of bacteria in specified group

AS: asymptomatic subjects; CagA: cytotoxin-associated gene A; NHS: non-infected healthy subjects; PU: peptic ulcer; SNP: single nucleotide polymorphism; TLR: Toll-like receptors