Table 5.

The frequencies of the genotypes and alleles at TLR4 SNP rs3804099 in H. pylori-infected subjects according to the CagA status of bacteria

		TLR4 gene polymorphism				Alleles
Groups	CagA status	TT	CT	CC	Total	C	T	p
PU	CagA+	53 (75.7%)	13 (18.6%)	4 (5.7%)	70 (100.0%)	119 (85.0%)	21 (15.0%)	*0.847
	CagA-	24 (80.0%)	5 (16.7%)	1 (3.3%)	30 (100.0%)	53 (88.3%)	7 (11.7%)	**0.535
	Total	77 (77.0%)	18 (18.0%)	5 (5.0%)	100 (100.0%)	172 (86.0%)	118 (59.0%)
AS	CagA+	63 (82.9%)	9 (11.8%)	4 (5.3%)	76 (100.0%)	135 (88.8%)	17 (11.2%)	*0.975
	CagA-	40 (81.6%)	6 (12.2%)	3 (6.1%)	49 (100.0%)	86 (87.75%)	12 (12.25%)	**0.798
	Total	103 (82.4%)	15 (12.0%)	7 (5.6%)	125 (100.0%)	221 (88.4%)	29 (11.6%)
NHS		95 (76.5%)	25 (20.0%)	5 (4.0%)	125 (100.0%)	215 (86.0%)	35 (14.0%)

^{*, **}comparison of the genotypes and alleles distribution at SNP rs4986790 between subjects infected with the CagA+ strains of H. pylori and those infected with CagA- strains of bacteria in specified group

AS: asymptomatic subjects; CagA: cytotoxin-associated gene A; NHS: non-infected healthy subjects; PU: peptic ulcer; SNP: single nucleotide polymorphism; TLR: Toll-like receptors