Figure 1. a, b.

Pedigree of the Moroccan family presenting the segregation of the novel duplication c.911dupG. Square: male, circle: female, open symbol: no tumor, colored symbol: patient with carcinomas, symbol with a diagonal: deceased. Numbers under symbols indicate the age at diagnosis. Plus/Minus signs indicates the presence/Absence of the mutation. The black arrow indicates the index proband (II-1) (a); The duplication results in a frameshift mutation starting from codon 304 and a premature stop three codons downstream (p.D304 fsX306)