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(A) Expression of ABCG2 is dependent on IKKβ activity. PC3 cells expressing ERβ2 or ERβ5 were exposed to 1 µM of the IKKβ inhibitor IMD-0354 for 24 hours and ABCG2 expression level was measured using real time PCR. (B) Western blot showing that IKKβ protein level is increased by expression of the variants. (C) Quantification of IKKbeta protein expression in PC3 stable cells versus GFP control.
