Table 1A. Top diseases and functions affected by ERβ2 from analysis of RNA-seq data.

Score	Focus molecules	Top diseases and functions
26	35	Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response
26	35	Cell Death and Survival, Auditory Disease, Auditory and Vestibular System Development and Function
23	34	Cell Cycle, Organismal Injury and Abnormalities, Cellular Response to Therapeutics
23	34	Cell Morphology, Cellular Development, Cellular Growth and Proliferation
23	34	Organismal Injury and Abnormalities, Cancer, Dermatological Diseases and Conditions
23	34	Cellular Movement, Cellular Assembly and Organization, Cell Morphology
23	34	Tissue Development, Cellular Movement, Cardiovascular System Development and Function
23	34	Cell Signaling, Antimicrobial Response, Inflammatory Response
22	33	Skeletal and Muscular System Development and Function, Embryonic Development, Organismal Development
22	33	Cancer, Organismal Injury and Abnormalities, Cellular Development
22	33	Gene Expression, Cardiovascular System Development and Function, Organ Morphology
22	33	Cardiac Enlargement, Cardiovascular Disease, Cardiovascular System Development and Function
20	32	Cellular Movement, Immune Cell Trafficking, Gastrointestinal Disease
20	32	Hematological System Development and Function, Humoral Immune Response, Lymphoid Tissue Structure and Development
20	32	Embryonic Development, Nervous System Development and Function, Organ Development
20	32	Cell Morphology, Cellular Movement, Organismal Injury and Abnormalities
20	32	Cell Death and Survival, Organismal Injury and Abnormalities, Cellular Function and Maintenance
20	32	Infectious Diseases, Respiratory Disease, Connective Tissue Development and Function
20	32	Cellular Development, Hematological System Development and Function, Lymphoid Tissue Structure and Development
18	31	Cell Death and Survival, Infectious Diseases, Tissue Morphology
18	31	Cellular Movement, Cellular Function and Maintenance, Molecular Transport
18	31	Cellular Movement, Cellular Development, Cellular Growth and Proliferation
18	31	Cellular Movement, Cardiovascular System Development and Function, Immune Cell Trafficking
18	31	Cell Death and Survival, Organismal Injury and Abnormalities, Cellular Development
18	31	Auditory Disease, Neurological Disease, Hereditary Disorder