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. 2018 Dec 4;9(6):952–964. doi: 10.14336/AD.2018.0215

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Copyright: © 2018 Manuel et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Comparison between FokI, Cdx2 and TaqI polymorphisms and the percentage of positive myonuclei. (A) The comparison between Cdx2 genotypes and muscle atrophy displays a significant group effect (GG =50%; GA= 38%; AA=18%; p=0,0004). Mann-Whitney test shows significant higher percentage of muscle atrophy (Type I = 17% vs Type II = 33%) in patients with GG genotype respect to patients with GA genotype (Type I = 17% vs Type II = 19%) (p=0,0035) and in patients with GA (Type I = 17% vs Type II = 19%) respect to patients with AA (Type I = 5% vs Type II = 13%) genotypes (p=0.0004). (B) The comparison between genotypes of FokI polymorphisms and muscle atrophy (CC =38%; CT= 45%; TT=46%) did not show a significant group effect (p=0,1080). Mann-Whitney test shows significant higher percentage of muscle atrophy in patients with CT genotype (Type I = 17% vs Type II = 28%) compared to patients with CC genotype (Type I = 17% vs Type II = 20%) (p= 0,0440). (C) The comparison between genotypes of TaqI polymorphisms and muscle atrophy (TT=50%; TC= 40%; CC=37%) did not reveal a significant group effect (p=0,1282). (D) Patients with GG/CT and GG/CC genotypes showed a significant higher percentage of type II atrophic fibers (Type II =35% and 25% respectively) respect to other genotypes combination (Type I =18% and 15% respectively).