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. 2018 Dec 4;9(6):1103–1121. doi: 10.14336/AD.2018.1110

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Copyright: © 2018 Junfen et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 10. — Embryonic development and organization structure of TE/SJ/ mesenchymal tissue system. Mesenchymal tissue system consists of mesodermal-derived all kinds of cells (Flk⁺Lin^-/KLF4⁺GMNN⁺) from postembryonic subtotipotent stem cells to functional cells in different stages of the embryonic development. In mammals, the intraembryonic coelom is a fluid-filled cavity with the somatic and the visceral mesoderm layers, which then forms TE/SJ/mesenchymal tissue system. Meanwhile, TE/SJ/mesenchymal tissue system constitutes the source of major organs and is the connecting pathway between them. It is involved in the proliferation and differentiation of stem cells, tissue regeneration, and functional reconstruction. It also participates in human immune surveillance, cellular senescence and tissue metabolic.