Table 3.
Correlation between neuropsychological performance and cortical thickness in mild cognitive impairment.
| CMMSE | CDR-Sum of boxes | ADAS-Cog | CVFT | Forward digit span |
Backward Digit span |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||||
| Brain region | Left | Right | Left | Right | Left | Right | Left | Right | Left | Right | Left | Right |
| Caudal anterior cingulate gyrus | -.077 | .075 | -.005 | .042 | -.139 | -.047 | .041 | .075 | -.108 | -.213 | -.104 | .172 |
| Caudal middle frontal gyrus | -.202 | -.171 | .309 | .302 | -.061 | .142 | -.108 | -.152 | -.022 | -.184 | -.059 | .018 |
| Cuneus | -.050 | .032 | -.062 | -.051 | .062 | -.097 | .209 | .221 | -.151 | -.090 | .065 | .120 |
| Entorthinal area | .173 | .323 | -.262 | -.366 | *-.413 | -.259 | .349 | .335 | .101 | .246 | -.301 | -.228 |
| Fusiform gyrus | .213 | .239 | -.159 | -.337 | -.137 | -.204 | .106 | .178 | .156 | .162 | -.125 | -.016 |
| Inferior parietal lobe | .096 | .029 | .091 | .083 | .003 | .058 | .163 | .117 | -.109 | -.110 | -.059 | .074 |
| Inferior temporal gyrus | .191 | *.508 | -.023 | -.198 | -.216 | -.369 | .350 | .262 | .023 | .214 | -.102 | .101 |
| Isthmus cingulate gyrus | .336 | .201 | -.118 | -.116 | -.277 | -.193 | -.043 | -.032 | .115 | .134 | .120 | .246 |
| Lateral occipital gyrus | .075 | -.017 | -.133 | .005 | -.035 | -.040 | .085 | -.016 | .007 | .092 | .085 | .225 |
| Lateral orbitofrontal gyrus | -.028 | -.040 | .202 | .003 | -.053 | -.044 | .231 | .125 | .085 | -.038 | .176 | -.021 |
| Lingual gyrus | .108 | .185 | -.111 | -.060 | -.119 | -.226 | .172 | .209 | .048 | .125 | .165 | .191 |
| Medial orbitofrontal gyrus | .076 | .046 | -.023 | .033 | .030 | -.148 | .334 | .376 | .038 | .066 | .118 | .047 |
| Middle temporal gyrus | .212 | .359 | .084 | -.182 | -.025 | .048 | .131 | .137 | -.072 | -.083 | -.137 | .180 |
| Parahippocampal gyrus | .215 | .200 | *-.413 | -.317 | -.061 | -.193 | -.111 | -.012 | .004 | .131 | -.337 | -.190 |
| Paracentral gyrus | -.144 | .043 | .122 | .197 | -.073 | -.044 | .005 | .048 | -.244 | -.098 | .005 | .054 |
| Pars opercularis | .031 | .001 | .160 | .101 | -.031 | -.117 | .114 | .126 | -.117 | .131 | .028 | -.187 |
| Pars orbitalis | -.013 | .059 | .311 | .221 | .029 | .099 | -.175 | -.050 | .277 | .245 | .315 | *.408 |
| Pars triangularis | .045 | .051 | .058 | -.009 | -.124 | -.155 | .170 | .159 | .013 | .138 | .227 | .302 |
| Pericalcarine | -.029 | -.251 | .048 | .072 | -.069 | -.117 | .173 | .194 | .010 | .010 | .194 | .038 |
| Postcentral gyrus | -.170 | -.188 | .131 | .107 | -.013 | .035 | .049 | .247 | -.114 | -.146 | .042 | .081 |
| Posterior cingulate gyrus | .039 | .040 | -.012 | .096 | -.116 | .057 | .100 | -.036 | -.046 | -.120 | -.067 | .181 |
| Precentral gyrus | -.044 | -.165 | .011 | .093 | .012 | -.088 | -.040 | .003 | -.193 | -.066 | -.090 | -.044 |
| Precuneus | .102 | .134 | -.032 | .060 | -.151 | -.115 | .203 | .184 | -.021 | -.106 | .032 | .022 |
| Rostral anterior cingulate gyrus | -.028 | -.070 | .284 | .239 | .024 | .214 | .016 | -.148 | -.096 | -.090 | .087 | -.014 |
| Rostral middle frontal gyrus | -.267 | -.100 | .185 | .116 | .071 | -.006 | .260 | *.398 | .017 | -.103 | .053 | .023 |
| Superior frontal gyrus | -.196 | -.190 | .391 | .255 | .032 | -.002 | .008 | .048 | -.210 | -.098 | .007 | -.119 |
| Superior parietal lobe | .002 | .029 | -.024 | .020 | -.089 | -.028 | .151 | .188 | -.008 | -.004 | .128 | .260 |
| Superior temporal gyrus | .247 | .232 | -.142 | -.242 | -.089 | .036 | .324 | .235 | .086 | .084 | .127 | .050 |
| Supramarginal gyrus | .092 | .026 | .167 | -.027 | -.174 | -.039 | .175 | .112 | -.021 | .109 | .062 | .149 |
| Frontal pole | .104 | .176 | -.150 | -.089 | .042 | -.080 | .047 | .324 | .056 | -.049 | .323 | -.005 |
| Temporal pole | .115 | .256 | -.215 | -.175 | -.187 | -.209 | .356 | 252 | .208 | .085 | .021 | -.041 |
| Transverse temporal gyrus | -.267 | -.188 | .198 | .089 | .131 | .251 | .029 | -.170 | -.173 | -.002 | .254 | .156 |
| Insula | .092 | .116 | .237 | -.012 | -.162 | -.299 | .276 | .322 | -.051 | .079 | .007 | -.078 |
*
p<0.01. ADAS-Cog - Chinese version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale; CDR - Clinical Dementia Rating; CMMSE - Cantonese version of the Mini-Mental State Examination; CVFT - Category Verbal Fluency Test