Table 4.
Correlation between neuropsychological performance and cortical thickness in healthy control.
| CMMSE | CDR-Sum of boxes | ADAS-Cog | CVFT | Forward digit span |
Backward Digit span |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||||
| Brain region | Left | Right | Left | Right | Left | Right | Left | Right | Left | Right | Left | Right |
| Caudal anterior cingulate gyrus | .010 | -.062 | -.159 | -.177 | .104 | .257 | .131 | -.166 | .110 | -.063 | -.076 | -.133 |
| Caudal middle frontal gyrus | -.066 | .116 | .220 | .164 | .182 | .106 | -.031 | -.043 | -.314 | -.253 | .116 | .072 |
| Cuneus | -.060 | .041 | .185 | .025 | .169 | .095 | .021 | .056 | -.230 | -.057 | .155 | .143 |
| Entorthinal area | -.252 | -.175 | .161 | .162 | .272 | .211 | -.229 | -.227 | -.091 | -.069 | -.096 | -.210 |
| Fusiform gyrus | -.015 | -.027 | .122 | .131 | .268 | .171 | -.081 | -.100 | -.183 | -.242 | -.053 | -.100 |
| Inferior parietal lobe | -.055 | .128 | .158 | -.012 | .145 | .176 | -.024 | .006 | -.156 | -.009 | .081 | .182 |
| Inferior temporal gyrus | -.006 | .239 | .002 | -.230 | .073 | -.154 | -.199 | -.090 | -.104 | -.008 | .228 | .013 |
| Isthmus cingulate gyrus | -.139 | -.137 | .377 | .249 | .271 | .342 | -.148 | -.232 | -.293 | -.130 | .058 | .247 |
| Lateral occipital gyrus | .229 | .277 | -.108 | -.105 | .018 | .088 | .124 | .197 | .028 | -.009 | .259 | .277 |
| Lateral orbitofrontal gyrus | -.278 | -.234 | .389 | .284 | .153 | .126 | -.300 | -.049 | -.396 | -.416 | .127 | .076 |
| Lingual gyrus | -.079 | .222 | .105 | .001 | .197 | .131 | .122 | .246 | -.405 | .017 | -.004 | .216 |
| Medial orbitofrontal gyrus | -.191 | -.068 | .263 | -.046 | .122 | .121 | -.227 | -.182 | -.393 | *-.456 | -.003 | .079 |
| Middle temporal gyrus | -.125 | .043 | .309 | .006 | .248 | .085 | *-.445 | -.306 | -.195 | -.133 | .205 | .174 |
| Parahippocampal gyrus | -.180 | -.151 | .076 | -.007 | .109 | -.029 | -.293 | -.201 | -.241 | -.235 | -.046 | -.131 |
| Paracentral gyrus | .096 | -.086 | .036 | .124 | .233 | .116 | .130 | .044 | -.139 | -.235 | .287 | .065 |
| Pars opercularis | -.211 | .117 | .303 | .193 | .340 | .153 | -.094 | .042 | *-.496 | -.258 | .043 | -.005 |
| Pars orbitalis | -.228 | -.187 | .261 | .040 | -.043 | .064 | .064 | -.045 | -.225 | -.355 | .075 | .011 |
| Pars triangularis | -.200 | -.038 | .333 | .207 | .261 | .041 | -.008 | -.031 | -.367 | -.116 | -.116 | -.080 |
| Pericalcarine | -.177 | -.109 | .249 | .097 | .187 | .091 | .036 | .020 | -.237 | -.331 | -.040 | -.093 |
| Postcentral gyrus | .144 | -.103 | -.017 | .057 | -.011 | .181 | -.004 | .039 | -.009 | -.093 | .145 | -.027 |
| Posterior cingulate gyrus | -.061 | -.046 | .000 | .064 | .306 | .379 | -.074 | -.039 | -.044 | -.144 | .125 | .095 |
| Precentral gyrus | -.049 | .016 | .145 | .220 | .110 | .183 | -.031 | -.015 | -.326 | -.183 | .217 | .132 |
| Precuneus | .059 | -.028 | -.060 | .179 | .199 | .170 | .077 | .001 | -.091 | -.143 | .323 | .204 |
| Rostral anterior cingulate gyrus | -.108 | -.117 | -.111 | -.086 | .068 | -.035 | -.142 | .023 | -.189 | -.201 | -.171 | -.090 |
| Rostral middle frontal gyrus | -.276 | .054 | .267 | .064 | .037 | -.003 | -.181 | -.092 | *-.422 | -.162 | -.183 | .247 |
| Superior frontal gyrus | .063 | -.001 | .023 | .158 | .137 | .196 | -.025 | -.117 | -.166 | -.295 | .092 | .088 |
| Superior parietal lobe | .092 | -.037 | .092 | .100 | .168 | .173 | .039 | .021 | -.074 | -.173 | .267 | .271 |
| Superior temporal gyrus | .136 | .213 | .093 | -.188 | .202 | .177 | .008 | -.029 | -.142 | .205 | .011 | .126 |
| Supramarginal gyrus | .093 | -.020 | .134 | -.105 | .187 | .045 | -.096 | -.103 | -.084 | -.092 | .056 | .038 |
| Frontal pole | -.051 | .030 | -.051 | -.074 | .037 | -.174 | -.238 | .074 | -.132 | -.086 | .231 | .259 |
| Temporal pole | -.007 | .131 | -.037 | -.069 | .080 | -.021 | -.198 | -.226 | .025 | .076 | .105 | .101 |
| Transverse temporal gyrus | -.033 | .232 | .051 | -.289 | .131 | .051 | .022 | .235 | -.118 | .214 | .026 | .260 |
| Insula | .057 | -.078 | .038 | .206 | -.060 | .132 | -.220 | -.274 | -.155 | -.229 | -.008 | -.083 |
*
p<0.01 ADAS-Cog - Chinese version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale; CDR - Clinical Dementia Rating; CMMSE - Cantonese version of the Mini-Mental State Examination; CVFT - Category Verbal Fluency Test