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. 2018 Dec 4;9(6):1010–1019. doi: 10.14336/AD.2018.0204

Table 3.

Multivariable analyses of the association between various factors and leukocyte telomere length in HIV-uninfected participants according to age group.

Percentage
change (95% CI)a
P
All HIV-uninfected participants
 Age group (55-82 vs 40-54 years) -4.9 (-15.2 to 6.7) 0.396
 Junior middle school or above -14.0 (-22.8 to -4.3) 0.006
 Depressive symptoms as a continuous variable -2.5 (-3.8 to -1.2) <.001
 Insomnia symptoms 8.4 (-13.9 to 36.5) 0.492
 Insomnia symptoms × age group interaction -17.9 (-41.3 to 14.9) 0.250
HIV-uninfected participants aged 40-54 years
 Age as a continuous variable -1.6 (3.3 to 0.1) 0.064
 Depressive symptoms as a continuous variable -2.4 (-4.0 to -0.7) 0.006
 Insomnia symptoms 7.3 (-14.8 to 35.0) 0.550
HIV-uninfected participants aged 55-82 years
Model 1b
 Age as a continuous variable -0.9 (-2.2 to 0.4) 0.195
 Junior middle school or above -29.9 (-41.0 to -16.7) <.001
 WHR above the cutoff -20.7 (-33.6 to -5.3) 0.012
 Insomnia symptoms -9.8 (-30.0 to 16.2) 0.428
Model 2b
 Age as a continuous variable -0.7 (-2.0 to 0.7) 0.314
 Junior middle school or above -27.9 (-39.4 to -14.3) <.001
 WHR above the cutoff -22.1 (-34.5 to -7.0) 0.006
 Depressive symptoms as a continuous variable -2.0 (-4.2 to 0.3) 0.090
a

Other variables considered in model selection included age, gender, education, smoking history, WHR above the cutoff, insomnia symptoms, and depressive symptoms, which were selected by univariable linear regression models with P <0.15 (See Table S3). Backward selection was used with retention at P <0.10. Age and insomnia symptoms were enforced and included in the final model where appropriate. Only variables included in final model were presented.

b

When both insomnia and depressive symptoms were simultaneously included in the model, they remained insignificant (P=0.730, and P=0.116, respectively). CI, confidence interval; WHR, waist to hip circumference ratio.