Table 5.

Adjusted structural equation model for the mediated effect of arsenic exposure on birth gestational age through variation of DNAm of CpGs in miR124-3 and MCC in the validation phase (n = 569).

Pathway	Effect	β Coefficient	P
		(95% CIs)
miR124-3
log2(water arsenic) → miR124-3	Direct	0.05 (0.01, 0.10)	0.028
MCC
log2(water arsenic) → MCC	Direct	0.06 (0.03, 0.09)	<0.001
SNP rs1057827 → MCC (reference: AA)
G/G	Direct	0.53 (0.12, 0.94)	0.011
A/G	Direct	0.11 (−0.06, 0.27)	0.198
Maternal weight gain
log2(water arsenic) → Weight gain	Direct	−0.15 (−0.23, −0.07)	<0.001
Birth type (caesarean vs. vaginal) → Weight gain	Direct	0.57 (0.09, 1.09)	0.029
Gestational age
log2(water arsenic) → Gestational age	Direct	−0.08 (−0.14, −0.02)	0.011
miR124-3 → Gestational age	Direct	−0.29 (−0.50, −0.09)	0.005
MCC → Gestational age	Direct	−0.17 (−0.44, 0.11)	0.242
Sex (male vs. female) → Gestational age	Direct	0.08 (−0.23, 0.40)	0.600
Weight gain → Gestational age	Direct	0.23 (0.17, 0.30)	<0.001
Birth type (caesarean section vs. vaginal) → Gestational age	Direct	0.64 (0.32, 0.95)	<0.001
Maternal education (>primary vs. ≤primary) → Gestational age	Direct	0.47 (0.15, 0.80)	0.004
log2(water arsenic) → Weight gain → Gestational age	Indirect	−0.04 (−0.06, −0.02)	0.001
log2(water arsenic) → miR124-3 → Gestational age	Indirect	−0.02 (−0.03, 0.00)	0.061
log2(water arsenic) → MCC → Gestational age	Indirect	−0.01 (−0.03, 0.01)	0.276