Table 1. Association of CDK12 expression with DNA repair proteins in unselected and TNBC.
| CDK12 Absent (0) No. of cases (%) |
CDK12 High (7/8) No. of cases (%) |
p-value | |
|---|---|---|---|
| Unselected Series | |||
| BRCA1 (n= 170) | 0.249 | ||
| Negative | 27 (51.9) | 50 (42.4) | |
| Positive | 25 (48.1) | 68 (57.6) | |
| PARP1 cleaved (n= 170) | 0.003** | ||
| Negative | 18 (30) | 13 (11.8) | |
| Positive | 42 (70) | 97 (88.2) | |
| PARP1 non-cleaved (n= 175) | 0.005** | ||
| Negative | 36 (62.1) | 46 (39.3) | |
| Positive | 22 (37.9) | 71 (60.7) | |
| ATR (n= 173) | <0.001** | ||
| Negative | 46 (70.8) | 45 (41.7) | |
| Positive | 19 (29.2) | 63 (58.3) | |
| APE1 (n= 89) | 0.02* | ||
| Negative | 10 (38.5) | 10 (15.9) | |
| Positive | 16 (61.5) | 53 (84.1) | |
| Ku70/Ku80 (n= 153) | 0.001** | ||
| Negative | 18 (34.0) | 11 (11.0) | |
| Positive | 35 (66.0) | 89 (89.0) | |
| DNA-PK (n= 156) | 0.002** | ||
| Negative | 17 (32.1) | 12 (11.7) | |
| Positive | 36 (67.9) | 91 (88.3) | |
| SMC6 cytoplasmic (n= 166) | 0.002** | ||
| Negative | 30 (54.5) | 33 (29.7) | |
| Positive | 25 (45.5) | 78 (70.3) | |
| SMC6 nuclear (n= 166) | < 0.001** | ||
| Negative | 33 (60.0) | 34 (30.6) | |
| Positive | 22 (40.0) | 77 (69.4) | |
| γH2AX (n= 150) | 0.002** | ||
| Negative | 24 (47.1) | 22 (22.2) | |
| Positive | 27 (52.9) | 77 (77.8) | |
| TP53 (n= 209) | 0.001** | ||
| Negative | 56 (80.0) | 80 (57.6) | |
| Positive | 14 (20.0) | 59 (42.4) | |
| CHEK1 cytoplasmic (n= 103) | 0.321 | ||
| Negative | 29 (50.9) | 44 (42.7) | |
| Positive | 28 (49.1) | 59 (57.3) | |
| CHEK1 nuclear (n= 161) | 0.927 | ||
| Negative | 48 (84.2) | 87 (83.7) | |
| Positive | 9 (15.8) | 17 (16.3) | |
| CHEK2 (n= 108) | 0.345 | ||
| Negative | 31 (50.8) | 63 (58.3) | |
| Positive | 30 (49.2) | 45 (41.7) | |
| Triple Negative Breast Cancer | |||
| BRCA1 (n= 28) | 0.430 | ||
| Negative | 10 (71.4) | 8 (57.1) | |
| Positive | 4 (28.6) | 6 (42.9) | |
| PARP1 cleaved (n= 28) | 0.378 | ||
| Negative | 8 (50.0) | 4 (33.3) | |
| Positive | 8 (50.0) | 8 (66.7) | |
| PARP1 non-cleaved (n= 29) | 0.103 | ||
| Negative | 11 (68.8) | 5 (38.5) | |
| Positive | 5 (31.2) | 8 (61.5) | |
| ATR (n= 33) | 0.018* | ||
| Negative | 18 (90.0) | 7 (53.8) | |
| Positive | 2 (10.0) | 6 (46.2) | |
| APE1 (n= 17) | 0.453 | ||
| Negative | 2 (25.0) | 1 (11.1) | |
| Positive | 6 (75.0) | 8 (88.9) | |
| Ku70/Ku80 (n= 27) | 0.010* | ||
| Negative | 8 (47.1) | 0 (0.0) | |
| Positive | 9 (52.9) | 10 (100.0) | |
| DNA-PK (n= 31) | 0.283 | ||
| Negative | 6 (37.5) | 3 (25.0) | |
| Positive | 10 (62.5) | 12 (75.0) | |
| SMC6 cytoplasmic (n= 31) | 0.018* | ||
| Negative | 9 (60.0) | 3 (23.1) | |
| Positive | 6 (40.0) | 13 (76.9) | |
| SMC6 nuclear (n= 31) | 0.045* | ||
| Negative | 11 (73.3) | 6 (37.5) | |
| Positive | 4 (26.7) | 10 (62.5) | |
| γH2AX (n= 29) | 0.089 | ||
| Negative | 9 (60.0) | 4 (28.6) | |
| Positive | 6 (40.0) | 10 (71.4) | |
| TP53 (n= 36) | 0.187 | ||
| Negative | 12 (63.2) | 7 (41.2) | |
| Positive | 7 (36.8) | 10 (58.8) | |
| CHEK1 cytoplasmic (n= 27) | 0.384 | ||
| Negative | 8 (47.1) | 3 (30.0) | |
| Positive | 9 (52.9) | 7 (70.0) | |
| CHEK1 nuclear (n= 28) | 0.068 | ||
| Negative | 17 (100.0) | 9 (81.8) | |
| Positive | 0 (0.0) | 2 (18.2) | |
| CHEK2 (n= 32) | 0.961 | ||
| Negative | 13 (68.4) | 9 (69.2) | |
| Positive | 6 (31.6) | 4 (30.8) | |