Table 2. Circulating glycer-AGEs concentration and the risk of cancers of the colorectum, colon, and rectum.
| Glycer-AGEs |
|||||
|---|---|---|---|---|---|
| Type of Cancer | Q1 (reference) OR |
Q2 OR (95% CI) |
Q3 OR (95% CI) |
Q4 OR (95% CI) |
ptrend |
| Colorectum | |||||
| Cut-point [U/mL]a | ≤5.42 | >5.42 and ≤7.03 | >7.03 and ≤8.65 | >8.65 | |
| Mean (SD), median [U/mL] | 4.3 (0.9), 4.4 | 6.3 (0.5), 6.3 | 7.8 (0.4), 7.7 | 10.5 (1.7), 10.0 | |
| Number of cases/controls | 249/264 | 301/264 | 237/263 | 266/263 | |
| Matching factorsb | 1.00 | 1.19 (0.94-1.50) | 0.95 (0.74-1.23) | 1.07 (0.81-1.42) | 0.95 |
| Multivariate adjustedc | 1.00 | 1.18 (0.92-1.51) | 0.94 (0.72-1.24) | 1.10 (0.82-1.49) | 0.87 |
| Colon | |||||
| Cut-point [U/mL]a | ≤5.48 | >5.48 and ≤6.99 | >6.99 and ≤8.68 | >8.68 | |
| Mean (SD), median [U/mL] | 4.3 (0.9), 4.5 | 6.3 (0.5), 6.2 | 7.7 (0.5), 7.7 | 10.5 (1.7), 10.0 | |
| Number of cases/controls | 174/166 | 184/165 | 157/164 | 144/164 | |
| Matching factorsb | 1.00 | 1.03 (0.77-1.37) | 0.88 (0.64-1.20) | 0.78 (0.55-1.11) | 0.12 |
| Multivariate adjustedc | 1.00 | 1.04 (0.76-1.42) | 0.86 (0.61-1.22) | 0.83 (0.57-1.22) | 0.25 |
| Rectum | |||||
| Cut-point [U/mL]a | ≤5.36 | >5.36 and ≤7.12 | >7.12 and ≤8.61 | >8.61 | |
| Mean (SD), median [U/mL] | 4.2 (1.0), 4.4 | 6.3 (0.5), 6.4 | 7.8 (0.4), 7.7 | 10.3 (1.7), 9.5 | |
| Number of cases/controls | 77/99 | 115/100 | 79/98 | 125/99 | |
| Matching factorsb | 1.00 | 1.49 (0.99-2.23) | 1.14 (0.73-1.80) | 1.90 (1.17-3.10) | 0.03 |
| Multivariate adjustedc | 1.00 | 1.47 (0.96-2.27) | 1.11 (0.68-1.80) | 1.90 (1.14-3.19) | 0.04 |
a
Based on control participants only
b
Model based on matching factors (age, gender, administrative centre, time of the day at blood collection, fasting status, and menopausal status among women) only
c
Model based on matching factors plus adjustments for smoking status/duration/intensity, body mass index, total physical activity, education level, diabetes status, total dietary energy consumption, and intakes of alcohol, red and processed meat, fibre, and fruits and vegetable
Abbreviation: Glycer-AGEs = glyceraldehyde-derived advanced glycation end-products; Q = quartile; OR = odds ratio; CI = confidence interval