Table 3. Associations of individual uric acid related SNPs with circulating uric acid and incident type 2 diabetes.
| Gene | Chr | SNP | Uric acid raising / other allele | Beta (95%CI) for uric acid concentrations * | P-value † | HR (95%CI) for incident diabetes ‡ |
|---|---|---|---|---|---|---|
| GCKR | 2 | rs780094 | T/C | 0.05 (0.02, 0.09) | 0.01 | 0.98 (0.93, 1.03) |
| SLC2A9 | 4 | rs734553 | T/G | 0.36 (0.32, 0.40) | < 0.001 | 1.02 (0.95, 1.09) |
| ABCG2 | 4 | rs2231142 | T/G | 0.19 (0.13, 0.25) | < 0.001 | 0.93 (0.86, 1.01) |
| LRRC16A | 6 | rs742132 | A/G | 0.04 (0.001, 0.08) | 0.04 | 1.00 (0.95, 1.06) |
| RREB1 | 6 | rs675209 | T/C | 0.08 (0.04, 0.12) | < 0.001 | 1.03 (0.98, 1.08) |
| SLC16A9 | 10 | rs12356193 | A/G | 0.06 (0.01, 0.11) | 0.01 | 1.03 (0.97, 1.09) |
| SLC22A11 | 11 | rs17300741 | A/G | 0.09 (0.05, 0.12) | < 0.001 | 1.00 (0.96, 1.05) |
| PDZK1 | 1 | rs12129861 | G/A | 0.03 (0.004, 0.08) | 0.03 | 1.04 (0.97, 1.12) |
| SLC17A1 | 6 | rs1183201 | T/A | 0.07 (0.04, 0.11) | < 0.001 | 0.97 (0.93, 1.01) |
| SLC22A12 | 11 | rs505802 | C/T | 0.05 (0.01, 0.09) | 0.01 | 1.00 (0.91, 1.09) |
| INHBC | 12 | rs1106766 | C/T | 0.06 (0.02, 0.11) | 0.01 | 1.07 (1.01, 1.13) |
| ORC4L | 2 | rs2307394 | C/T | 0.03 (-0.01, 0.06) | 0.15 | 0.99 (0.93, 1.05) |
| SFMBT1 | 3 | rs6770152 | G/T | 0.05 (0.01, 0.09) | 0.01 | 1.06 (1.00, 1.13) |
| VEGFA | 6 | rs729761 | G/T | 0.07 (0.03, 0.11) | < 0.01 | 0.92 (0.87, 0.97) |
| BAZ1B | 7 | rs1178977 | A/G | 0.05 (0.01, 0.10) | 0.02 | 1.00 (0.92, 1.09) |
| PRKAG2 | 7 | rs10480300 | T/C | 0.06 (0.03, 0.10) | 0.001 | 1.00 (0.95, 1.05) |
| STC1 | 8 | rs17786744 | G/A | 0.04 (0.01, 0.08) | 0.02 | 0.97 (0.93, 1.02) |
| OVOL1 | 11 | rs642803 | C/T | 0.03 (-0.01, 0.06) | 0.16 | 1.00 (0.95, 1.06) |
| ATXN2 | 12 | rs653178 | C/T | 0.03 (-0.01, 0.06) | 0.16 | 1.00 (0.95, 1.06) |
| UBE2Q2 | 15 | rs1394125 | A/G | 0.003 (-0.03, 0.04) | 0.86 | 0.99 (0.94, 1.03) |
| IGF1R | 15 | rs6598541 | A/G | 0.07 (0.03, 0.10) | 0.001 | 1.03 (0.98, 1.08) |
| NFAT5 | 16 | rs7193778 | C/T | 0.06 (0.01, 0.12) | 0.02 | 1.02 (0.95, 1.09) |
| MAF | 16 | rs7188445 | G/A | 0.03 (-0.01, 0.07) | 0.16 | 0.98 (0.92, 1.04) |
| BCAS3 | 17 | rs2079742 | T/C | 0.02 (-0.02, 0.07) | 0.30 | 1.01 (0.96, 1.08) |
*
Beta obtained from linear regression with uric acid modeled per 59.48 μmol/L (1 mg/dL) increase, and SNPs modeled per uric acid increasing allele (additive model), adjusted for study center, among 10,235 subcohort participants
†
P-value for association uric acid related SNPs with uric acid concentrations
‡
HR and 95%CI obtained from random effects meta-analysis using modified Cox regression, adjusted for study center, among 17,118 participants of which 7,319 were incident diabetes cases.