. Author manuscript; available in PMC: 2018 Dec 7.

Published in final edited form as: Int J Cardiol. 2015 May 31;196:108–114. doi: 10.1016/j.ijcard.2015.05.166

Table 3.

Quintiles of dietary magnesium intake (range and mean quintile intake) at baseline (1993-1997) and stroke risk (HR and 95%CI), follow-up March 2008, in 4443 men and women, aged 40-75 in EPIC-Norfolk cohort.

Men

	Q1	Q2	Q3	Q4	Q5

	85-242 mg 206 mg n=400	243-284 mg 266 mg n=400	285-328 mg 307 mg n=400	329-385 mg 355 mg n=400	386-829 456 mg n=400	P trend

Stroke Events	126 (30.6)	111 (26.9)	93 (22.6)	85 (20.6)	75 (18.3)
Model 1¹	1.0 (reference)	0.85 (0.60-1.20)	0.70 (0.49-1.00)	0.86 (0.60-1.24)	0.80 (0.55-1.16)	0.22
Model 2²	1.0 (reference)	0.86 (0.60-1.20)	0.68 (0.47-0.99)	0.81 (0.56-1.17)	0.74 (0.50-1.09)	0.11
Model 3³	1.0 (reference)	0.87 (0.61-1.25)	0.73 (0.50-1.06)	0.80 (0.55-1.17)	0.81 (0.53-1.22)	0.21

Women

	48-204 mg 176 mg n=489	205-240 mg 223 mg n=489	241-274 mg 258 mg n=489	275-319 mg 295 mg n=489	320-692 mg 374 mg n=488

Stroke Events	152 (30.5)	102 (20.5)	87 (17.5)	82 (16.5)	88 (17.7)
Model 1¹	1.0 (reference)	0.74 (0.53-1.05)	0.74 (0.51-1.06)	0.84 (0.59-1.20)	0.83 (0.57-1.20)	0.39
Model 2²	1.0 (reference)	0.71 (0.50-1.01)	0.71 (0.49-1.03)	0.82 (0.57-1.17)	0.76 (0.52-1.11)	0.23
Model 3³	1.0 (reference)	0.72 (0.50-1.04)	0.73 (0.50-1.08)	0.86 (0.59-1.26)	0.82 (0.54-1.24)	0.45

model 1: age, BMI, education status, physical activity, smoking status, alcohol intake

model 2: model 1 + serum total cholesterol, baseline MI or diabetes, family history stroke, or MI

model 3: model 2 + SBP, DBP, aspirin use >3 months, antihypertensive medication, ratio Ca:Mg and magnesium and calcium supplement use (including contribution from medication)