Table 4.
Stroke risk (HR 95% CI) by magnesium groups (range and mean intake), bottom 10% (Group 1 reference category) and 3 groups of 30% intakes each, in 4443 men and women, aged 40-75 in EPIC-Norfolk cohort.
| Men |
Group 1 85-214 mg 181 mg n=199 |
Group 2 215-285 mg 254 mg n=605 |
Group 3 286-353 mg 318 mg n=591 |
Group 4 354-828mg 427 mg n=605 |
P trend |
| Stroke Events | 65 (32.7%) | 157 (26.0%) | 123 (20.8%) | 104 (17.2%) | |
| Model 11 | 1.00 | 0.73 (0.50-1.07) | 0.63 (0.43-0.94)*4 | 0.67 (0.44-1.01) *4 | 0.07 |
| Model 22 | 1.00 | 0.72 (0.48-1.07) | 0.61 (0.41-0.92) *4 | 0.61 (0.40-0.94) *4 | 0.03 |
| Model 33 | 1.00 | 0.67 (0.45-1.01)* | 0.60 (0.40-0.90) *4 | 0.59 (0.38-0.93) *4 | 0.04 |
| Women |
Group 1 48-180 mg 156 mg n=232 |
Group 2 181-240 mg 213 mg n=745 |
Group 3 241-294 mg 267 mg n=740 |
Group 4 295-691 mg 352 mg n=726 |
|
| Stroke Events | 73 (31.5%) | 165 (22.2%) | 126 (17.0%) | 115 (15.8%) | |
| Model 11 | 1.00 | 0.73 (0.49-1.08) | 0.70 (0.46-1.06) | 0.74 (0.48-1.12) | 0.27 |
| Model 22 | 1.00 | 0.67 (0.45-1.00) *4 | 0.65 (0.43-0.98) *4 | 0.66 (0.43-1.02) | 0.14 |
| Model 33 | 1.00 | 0.65 (0.43-0.99) *4 | 0.65 (0.42-1.01) | 0.69 (0.44-1.09) | 0.27 |
1
model 1: age, BMI, education status, physical activity, smoking status, alcohol intake
2
model 2: model 1 + serum total cholesterol, baseline MI or diabetes, family history stroke, or MI
3
model 3: model 2 + SBP, DBP, aspirin use >3 months, antihypertensive medication, ratio Ca:Mg and magnesium and calcium supplement use (including contribution from medication)
4
P value for significance compared with reference (Group 1): *= P value ≤0.05