Table 3. Association between CRP genetic variation and risk of colorectal cancer (n=1,454).
| CRP genotype | % difference in CRPa | Colorectal cancer | Men | Women | Colon cancer | Rectal cancer | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ca/Co | OR | (95% CI) | Ca/Co | OR | (95% CI) | Ca/Co | OR | (95% CI) | Ca/Co | OR | (95% CI) | Ca/Co | OR | (95% CI) | ||
| rs1205 | ||||||||||||||||
| CC | 0 | 358/302 | 1.00 | (Ref.) | 161/129 | 1.00 | (Ref.) | 197/173 | 1.00 | (Ref.) | 241/201 | 1.00 | (Ref.) | 117/101 | 1.00 | (Ref.) |
| CT | -21 | 292/342 | 0.74 | (0.60-0.92) | 131/165 | 0.64 | (0.46-0.89) | 161/177 | 0.83 | (0.62-1.10) | 201/227 | 0.75 | (0.58-0.98) | 91/115 | 0.71 | (0.49-1.04) |
| TT | -44 | 71/81 | 0.76 | (0.53-1.08) | 37/35 | 0.84 | (0.50-1.41) | 34/46 | 0.67 | (0.41-1.10) | 38/54 | 0.59 | (0.37-0.93) | 33/27 | 1.11 | (0.63-1.97) |
| p-trend | 0.01 | 0.09 | 0.07 | 0.01 | 0.60 | |||||||||||
| per T allele | -19 | 0.82 | (0.70-0.96) | 0.82 | (0.65-1.03) | 0.82 | (0.67-1.01) | 0.76 | (0.63-0.93) | 0.93 | (0.72-1.21) | |||||
| rs1800947 | ||||||||||||||||
| CC | 0 | 636/633 | 1.00 | (Ref.) | 289/286 | 1.00 | (Ref.) | 347/347 | 1.00 | (Ref.) | 426/429 | 1.00 | (Ref.) | 210/204 | 1.00 | (Ref.) |
| CG/GG | -35 | 84/93 | 0.91 | (0.67-1.23) | 39/44 | 0.88 | (0.56-1.37) | 45/49 | 0.93 | (0.61-1.42) | 54/54 | 1.02 | (0.69-1.51) | 30/39 | 0.75 | (0.46-1.24) |
| p-trend | 0.77 | 0.75 | 0.92 | 0.78 | 0.41 | |||||||||||
| per G allele | -30 | 0.96 | (0.72-1.28) | 0.93 | (0.61-1.42) | 0.98 | (0.66-1.45) | 1.05 | (0.73-1.53) | 0.82 | (0.52-1.31) | |||||
| rs1130864 | ||||||||||||||||
| GG | 0 | 315/346 | 1.00 | (Ref.) | 154/154 | 1.00 | (Ref.) | 161/192 | 1.00 | (Ref.) | 209/226 | 1.00 | (Ref.) | 106/120 | 1.00 | (Ref.) |
| GA/AA | 13 | 405/379 | 1.17 | (0.94-1.44) | 174/175 | 0.97 | (0.71-1.34) | 231/204 | 1.35 | (1.01-1.79) | 271/257 | 1.14 | (0.88-1.49) | 134/122 | 1.21 | (0.84-1.74) |
| p-trend | 0.04 | 0.42 | 0.04 | 0.14 | 0.14 | |||||||||||
| per A allele | 15 | 1.19 | (1.01-1.40) | 1.10 | (0.87-1.41) | 1.26 | (1.01-1.57) | 1.16 | (0.95-1.41) | 1.25 | (0.93-1.67) | |||||
| rs2808630 | ||||||||||||||||
| TT | 0 | 370/386 | 1.00 | (Ref.) | 171/175 | 1.00 | (Ref.) | 199/211 | 1.00 | (Ref.) | 245/265 | 1.00 | (Ref.) | 125/121 | 1.00 | (Ref.) |
| CT | -18 | 279/279 | 1.04 | (0.84-1.29) | 125/131 | 0.99 | (0.72-1.35) | 154/148 | 1.09 | (0.81-1.47) | 186/181 | 1.10 | (0.85-1.44) | 93/98 | 0.93 | (0.64-1.36) |
| CC | 12 | 70/58 | 1.26 | (0.86-1.85) | 32/23 | 1.45 | (0.83-2.52) | 38/35 | 1.11 | (0.65-1.89) | 48/35 | 1.53 | (0.95-2.46) | 22/23 | 0.88 | (0.46-1.68) |
| p-trend | 0.30 | 0.38 | 0.54 | 0.10 | 0.63 | |||||||||||
| per C allele | -30 | 1.09 | (0.93-1.27) | 1.11 | (0.88-1.39) | 1.07 | (0.86-1.33) | 1.18 | (0.97-1.43) | 0.94 | (0.71-1.23) | |||||
| rs3093077 | ||||||||||||||||
| AA | 0 | 634/621 | 1.00 | (Ref.) | 288/285 | 1.00 | (Ref.) | 346/336 | 1.00 | (Ref.) | 418/412 | 1.00 | (Ref.) | 216/209 | 1.00 | (Ref.) |
| AC/CC | 29 | 87/101 | 0.84 | (0.62-1.15) | 41/41 | 0.97 | (0.60-1.57) | 46/60 | 0.76 | (0.51-1.14) | 62/70 | 0.86 | (0.59-1.26) | 25/31 | 0.79 | (0.46-1.37) |
| p-trend | 0.29 | 0.90 | 0.21 | 0.47 | 0.41 | |||||||||||
| per C allele | 32 | 0.85 | (0.63-1.15) | 0.97 | (0.60-1.57) | 0.78 | (0.53-1.15) | 0.88 | (0.61-1.25) | 0.79 | (0.46-1.37) | |||||
| unweighted CRP-score | ||||||||||||||||
| 0 or 1 or 2 | 0 | 93/104 | 1.00 | (Ref.) | 48/44 | 1.00 | (Ref.) | 45/60 | 1.00 | (Ref.) | 54/67 | 1.00 | (Ref.) | 39/37 | 1.00 | (Ref.) |
| 3,4 | 23 | 342/379 | 1.02 | (0.75-1.39) | 154/181 | 0.84 | (0.54-1.31) | 188/198 | 1.26 | (0.81-1.96) | 233/251 | 1.17 | (0.79-1.73) | 109/128 | 0.83 | (0.50-1.37) |
| 5 | 25 | 165/153 | 1.20 | (0.84-1.70) | 71/68 | 1.01 | (0.60-1.70) | 94/85 | 1.43 | (0.88-2.33) | 108/100 | 1.34 | (0.86-2.11) | 57/53 | 1.01 | (0.57-1.77) |
| 6 or 7 | 46 | 121/90 | 1.50 | (1.01-2.22) | 56/37 | 1.39 | (0.77-2.50) | 65/53 | 1.62 | (0.94-2.76) | 85/65 | 1.63 | (1.01-2.65) | 36/25 | 1.32 | (0.66-2.66) |
| p-trend | 0.02 | 0.12 | 0.06 | 0.03 | 0.28 | |||||||||||
| per score unit | 13 | 1.08 | (1.00-1.17) | 1.08 | (0.96-1.22) | 1.09 | (0.98-1.21) | 1.10 | (1.00-1.21) | 1.06 | (0.93-1.21) | |||||
| weighted CRP-score | ||||||||||||||||
| Tertile 1 | 0 | 226/261 | 1.00 | (Ref.) | 111/124 | 1.00 | (Ref.) | 115/137 | 1.00 | (Ref.) | 144/166 | 1.00 | (Ref.) | 82/95 | 1.00 | (Ref.) |
| Tertile 2 | 23 | 187/190 | 1.14 | (0.86-1.49) | 79/86 | 1.05 | (0.70-1.58) | 108/104 | 1.21 | (0.84-1.75) | 127/128 | 1.16 | (0.83-1.62) | 60/62 | 1.09 | (0.68-1.75) |
| Tertile 3 | 33 | 308/275 | 1.27 | (1.00-1.62) | 139/120 | 1.28 | (0.89-1.84) | 169/155 | 1.26 | (0.91-1.75) | 209/189 | 1.27 | (0.94-1.72) | 99/86 | 1.27 | (0.84-1.92) |
| p-trend | 0.05 | 0.17 | 0.17 | 0.12 | 0.25 | |||||||||||
| per score unit | 65 | 1.15 | (0.99-1.35) | 1.20 | (0.95-1.52) | 1.11 | (0.90-1.37) | 1.17 | (0.96-1.42) | 1.12 | (0.86-1.46) | |||||
a
based on unadjusted mixed model
OR, odds ratio; models were conditional logistic regression models, controlled for matching factors, without further adjustment