Table 3:
Propensity-weighted sexual, urinary, and bowel function at 24 months by treatment type stratified by baseline function level
| Sexual Dysfunction | |||||
|---|---|---|---|---|---|
| 24 Month Functional Level | |||||
| Normal % (95% CI) | Intermediate % (95% CI) | Poor % (95% CI) | |||
| Baseline Functional Level | Normal | Active surveillance | 44.6 (43.3,45.7) | 30.3 (29.4,31.0) | 25.2 (24.4,26.1) |
| Brachytherapy | 36.2 (34.2,38.5) | 29.6 (27.2,31.9) | 34.2 (32.3,36.0) | ||
| Radical Prostatectomy | 9.4 (9.1,9.8) | 33.5 (32.9,34.0) | 57.1 (56.6,57.6) | ||
| External beam RT | 27.1 (26.2,28.1) | 45.7 (44.5,46.8) | 27.2 (26.6,27.9) | ||
| Intermediate | Active surveillance | 10.2 (9.4,10.9) | 43.9 (43.0,45.0) | 45.9 (45.0,46.7) | |
| Brachytherapy | 2.7 (1.5,3.9) | 46.7 (44.2,49.0) | 50.6 (48.5,53.0) | ||
| Radical Prostatectomy | 5.1 (4.7,5.7) | 18.0 (17.2,18.8) | 76.9 (76.1,77.6) | ||
| External beam RT | 6.6 (5.7,7.5) | 38.4 (37.3,39.7) | 55.0 (54.0,55.9) | ||
| Poor | Active surveillance | 2.6 (2.2,3.0) | 10.1 (9.6,10.8) | 87.2 (86.4,87.9) | |
| Brachytherapy | 1.3 (0.8,1.7) | 20.3 (19.5,21.1) | 78.5 (77.5,79.5) | ||
| Radical Prostatectomy | 1.0 (0.9,1.1) | 4.3 (3.9,4.8) | 94.7 (94.1,95.2) | ||
| External beam RT | 1.2 (0.9,1.5) | 13.8 (13.0,14.7) | 85.0 (84.2,85.9) | ||
| Urinary Obstruction and Irritation | |||||
| 24 Month Functional Level | |||||
| Normal % (95% CI) | Intermediate % (95% CI) | Poor % (95% CI) | |||
| Baseline Functional Level | Normal | Active surveillance | 42.0 (41.1,42.8) | 44.8 (43.8,45.7) | 13.2 (12.4,14.1) |
| Brachytherapy | 19.3 (17.8,20.9) | 56.9 (54.8,58.6) | 23.9 (22.4,25.3) | ||
| Radical Prostatectomy | 52.7 (52.3,53.2) | 39.1 (38.6,39.6) | 8.1 (7.7,8.6) | ||
| External beam RT | 48.8 (48.0,49.5) | 35.8 (34.8,36.7) | 15.4 (14.5,16.4) | ||
| Intermediate | Active surveillance | 17.0 (16.4,17.6) | 43.6 (42.7,44.5) | 39.4 (38.6,40.2) | |
| Brachytherapy | 18.3 (17.0,19.5) | 44.1 (42.1,46.1) | 37.6 (36.2,39.0) | ||
| Radical Prostatectomy | 30.9 (29.4,32.3) | 54.1 (52.5,55.9) | 15.0 (14.2,15.9) | ||
| External beam RT | 27.6 (26.7,28.6) | 44.6 (43.6,45.5) | 27.8 (26.8,28.7) | ||
| Poor | Active surveillance | 6.3 (5.6,7.0) | 37.0 (36.1,38.0) | 56.7 (55.8,57.7) | |
| Brachytherapy | 14.5 (13.6,15.4) | 33.9 (32.1,35.9) | 51.5 (50.3,52.8) | ||
| Radical Prostatectomy | 24.1 (23.3,24.8) | 51.6 (50.8,52.4) | 24.4 (23.8,24.9) | ||
| External beam RT | 9.2 (8.5,9.9) | 36.7 (35.8,37.7) | 54.1 (53.2,54.8) | ||
| Urinary Incontinence | |||||
| 24 Month Functional Level | |||||
| Normal % (95% CI) | Intermediate % (95% CI) | Poor % (95% CI) | |||
| Baseline Level | Normal | Active surveillance | 72.7 (71.8,73.5) | 20.3 (19.6,21.0) | 7.0 (6.7,7.4) |
| Brachytherapy | 64.8 (63.7,65.8) | 26.2 (25.2,27.2) | 9.0 (8.3,9.7) | ||
| Radical Prostatectomy | 34.3 (33.7,34.8) | 49.9 (49.2,50.6) | 15.8 (15.4,16.3) | ||
| External beam RT | 73.0 (72.3,73.7) | 19.9 (19.3,20.5) | 7.1 (6.6,7.4) | ||
| Intermediate | Active surveillance | 22.5 (21.1,23.7) | 51.4 (49.4,53.4) | 26.1 (24.6,27.6) | |
| Brachytherapy | 38.1 (34.7,41.7) | 32.0 (27.4,36.6) | 29.9 (26.7,33.4) | ||
| Radical Prostatectomy | 15.4 (14.5,16.2) | 67.4 (66.4,68.3) | 17.3 (16.6,17.8) | ||
| External beam RT | 32.2 (31.0,33.6) | 52.1 (51.0,53.3) | 15.7 (14.8,16.6) | ||
| Bowel Problems | |||||
| 24 Month Functional Level | |||||
| Normal % (95% CI) | Intermediate % (95% CI) | Poor % (95% CI) | |||
| Baseline Level | Normal | Active surveillance | 57.2 (56.2,58.2) | 33.5 (32.3,34.8) | 9.3 (8.7,9.9) |
| Brachytherapy | 46.8 (45.1,48.4) | 44.4 (42.7,46.4) | 8.9 (7.6,10.5) | ||
| Radical Prostatectomy | 57.4 (56.3,58.2) | 37.0 (36.1,38.0) | 5.6 (5.2,6.0) | ||
| External beam RT | 42.7 (41.8,43.5) | 39.9 (39.2,40.5) | 17.4 (16.7,18.2) | ||
| Intermediate | Active surveillance | 28.9 (28.1,29.5) | 54.8 (54.1,55.6) | 16.3 (15.5,17.1) | |
| Brachytherapy | 27.0 (26.1,27.8) | 56.9 (56.1,57.7) | 16.2 (15.7,16.7) | ||
| Radical Prostatectomy | 34.8 (34.4,35.2) | 50.5 (50.1,50.9) | 14.7 (14.3,15.1) | ||
| External beam RT | 19.9 (19.0,21.1) | 60.3 (59.1,61.5) | 19.8 (19.1,20.4) | ||
Abbreviations: RT, radiotherapy; CI, confidence interval.
Missing data were imputed.
Normal function describes a patient with essentially no dysfunction or distress in a domain. Intermediate function describes a patient with at least one distressful symptom but none very distressful. Poor function describes patients with at least one very distressful symptom.
Among active surveillance patients, 18.7% received treatment within 24 months: 6.2% radical prostatectomy, 6.9% external beam RT, 3.1% brachytherapy, and 2.4% other.