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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: Curr Opin Cell Biol. 2016 Apr 8;40:145–152. doi: 10.1016/j.ceb.2016.03.011

Figure 2. Telomeres adopt cell-cycle specific positions in yeast and mammals.

Figure 2.

(a) In cultured mammalian cells, telomeres localize both internally and at the periphery. In the absence of telomerase, ALT occurs near PML bodies where telomeres are spatially juxtaposed for recombination. The table underneath lists proposed functions of telomere locations. (b) In fission yeast and budding yeast, telomeres cluster at the NM away from the yeast centrosome (SPB); centromeres localize beneath the SPB. (c) During meiosis, the telomere bouquet forms. In yeast (top right inset), centromeres move away from the SPB as telomeres are gathered at the SPB. This switch of SPB-LINC partners provides a transient window where telomeres are in close proximity to centromeres. This proximity has been proposed to function in centromeric assembly; the bouquet itself is required for proper meiotic recombination and spindle formation. In mice (bottom right inset), telomere remodeling takes place upon bouquet formation. In pachytene, TRF1 appears as a cloud around telomeric FISH signals, while TERB1/2 and MAJIN appear tightly colocalized with these signals.