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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Sens Actuators B Chem. 2018 Oct 4;279:447–457. doi: 10.1016/j.snb.2018.09.121

Table 2.

Comparison with existing RCA-based miRNA detection methods

Methods LOD Dynamic range Sample analyzed Reference
B-RCAa 6 amol 0.025 to 1 pM Total RNA 18
P-ERCAb 0.24 zmol 0.3 zmol to 18 zmol Total RNA 19
D-RCAc 20 zmol 1 fM to 100 nM Total RNA 20
Gel particle-based RCA 15 zmol 300 aM to 40 pM Synthetic miRNA spiked serum 27
Paper-based Electrochemical biosensor 0.35fM 1.0 fM to10 nM Diluted human serum 31
Stem-loop RT-PCR 7 copies 0.013 fM to 13 pM total RNA, cell lysate and cells 12
MERCA 5–8 zmol 50 zmol to 5 fmol Total RNA; cell lysate; exosomes This work
a:

branched rolling circle amplification

b:

padlock probe-based exponential rolling circle amplification

c:

dumbbell rolling circle amplification