Table 1:
Baseline characteristics
| Plasma group (n=65) | Control group (n=60) | |
|---|---|---|
| Demographics | ||
| Age (years) | 33·0 (25·0–51·0) | 32·5 (25·5–42·0) |
| Body-mass index (kg/m2) | 27·1 (23·9–30·5) | 26·1(23·2–29·5) |
| Sex | ||
| Men | 52 (80%) | 51 (85%) |
| Women | 13 (20%) | 9 (15%) |
| Clinical characteristics | ||
| Comorbidities | 10 (15%) | 8 (13%) |
| Blunt injury | 30 (46%) | 32 (53%) |
| New injury severity score | 27·0 (10·0–41·0) | 27·0 (11·5–36·0) |
| Score >25 | 33 (51%) | 34 (57%) |
| Abbreviated injury scale maximum score | ||
| Head and neck | 0 (0–2) | 0 (0–2·5) |
| Traumatic brain injury* | 13 (20%) | 15 (25%) |
| Chest | 1 (0–3) | 3 (0–3) |
| Abdomen and pelvis | 0 (0–3) | 0 (0–3) |
| Extremities | 1 (0–3) | 0 (0–2) |
| Physiology and shock (at scene of injury) | ||
| Worst heart rate (beats per min) | 110 (98–120) | 112 (100–120) |
| Lowest SBP (mm Hg) | 64 (50–80) | 70 (55–80) |
| SBP≤70mmHg | 44 (68%) | 33 (55%) |
| Lowest temperature (°C) | 36·0 (34·8–36·6) | 36·0 (35·1–37·0) |
| Lowest Glasgow coma scale score | 14 (7–15) | 14 (8–15) |
| Haemoglobin concentration (g/dL) |
15·1 (13·5–15·7) | 14·2 (13·1–16·0) |
| Platelet count (× 103 per μL) | 301 (250–357) | 274 (218–336) |
| Coagulation (at scene of injury) | ||
| INR | 1·1 (1·0–1·2) | 1·1 (1·0–1·1) |
| INR >1.3 | 2/36 (6%) | 2/29 (7%) |
| Rapid thromboelastography | ||
| G (dynes/cm2) | 8·2 (6·8–10·6) | 8·7 (6·9–10·2) |
| Activated clotting time (s) | 121 (113–128) | 121 (113–128) |
| Maximum amplitude (mm) | 62 (57·5–68·0) | 63·5 (58·0–67·0) |
| Angle (°) | 70·6 (66·9–75·6) | 70·6 (66·1–74·3) |
| Lysis | ||
| LY30(%) | 2·2 (1·0–3·7) | 1·8 (0·9–3·7) |
| Hypenibrinolysis (LY30 >3·0%) | 15/43 (35%) | 11/37 (30%) |
| Physiological lysis (LY30 0·9–3·0%) | 20/43 (46%) | 17/37 (46%) |
| Lysis shutdown (Ly30 <0·9%) | 8/43 (19%) | 9/37 (24%) |
| Coagulation factor (% activity) | ||
| Fibrinogen (mg/dL) | 253 (224–310) | 278 (250–331) |
| II | 95·0 (85·0–105·0) | 98·0 (85·0–105·0) |
| V | 85·0 (73·0–99·0) | 91·5 (77·0–100·0) |
| VII | 101·5 (84·0–127·0) | 89·5 (80·0–114·0) |
| VIII | 396·8 (273·0–476·0) | 411·8 (353·2–464·6) |
| IX | 157·0 (128·0–180·0) | 160·5 (148·0–174·0) |
| XI | 126·5 (106·0–153·0) | 141·5 (100·0–168·0) |
| XIII† | None abnormal | None abnormal |
Data are median (IQR) or n (%). SBP=systolic blood pressure. INR=international normalised ratio. LY30=percentage of lysis 30 min after maximum amplitude.
*
Abbreviated injury scale for head ≥3.
†
Measured with qualitative assay.