Table 3. Univariate survival analysis by subgroups, comparing a high to a low serum MMP-14 value among 240 gastric cancer patients.

	High serum MMP-14
	HR	95% CI	p value
Age, years
<67	2.02	1.19–3.42	0.009
≥67	2.05	1.07–3.94	0.031
Gender
Male	2.74	1.54–4.87	0.001
Female	1.42	0.79–2.54	0.236
Stage
I	N/A
II	2.32	0.54–10.0	0.261
III	1.26	0.72–2.20	0.417
IV	1.78	0.88–3.57	0.107
Tumor classification (pT)
pT1–2	2.23	0.62–8.02	0.218
pT3–4	1.74	1.13–2.67	0.012
Lymph node metastasis (pN)
pN0	1.45	0.42–5.01	0.559
pN1–3	1.96	1.24–3.09	0.004
Distant metastasis (pM)
pM0	1.64	0.98–2.74	0.058
pM1	1.78	0.88–3.57	0.107
Laurén classification
Intestinal	3.54	1.51–8.33	0.004
Diffuse	1.54	0.96–2.45	0.071

Abbreviations: MMP-14 = Matrix metalloproteinase-14, HR = hazard ratio, CI = confidence interval, N/A = not available