Fig 5. Antibody reactivity to DENV and ZIKV polyproteins of animals with recent DENV infection.
Three macaques (F1, F2, and F3), with history of challenge and rechallenge with ZIKV-FP 12 and 9.5 months prior, were infected with DENV-2 and serum samples taken before DENV infection and at 28 dpi were assessed. Reactivity of these animals against peptides representing the envelope, NS2B, and NS3 proteins of DENV-2 (A) and ZIKV-FP (B) is shown. The ZIKV NS2B1427-1451RD25 epitope (in B) is highlighted in grey; the corresponding region in the DENV NS2B protein is likewise highlighted (in A).