Table 2. Table of parameters used in model.

Symbol	Parameter	Value	Reference/Notes
Vspine	Volume of Spine	1 to 5×10-20 m3	(Bartol et al., 2015)
VPSD	Volume of PSD (Thickness $100\mathrm{nm}$. Surface area 0.05µm2)	1 to 5×10-21 m3	Farley, 2015; Bartol et al., 2015
NCaMKII	Total CaMKII holoenzymes in PSD/Spine	100 ± 18	Farley, 2015
NPP1	Total PP1 in PSD Total PP1 in Spine	4 to 20× NCaMKII 10 to 100× NCaMKII	This paper This paper
I1	Concentration of free I1	10 µM	Miller et al., 2005
VCaN	Activity of calcineurin divided by its	1	Miller et al., 2005
VCaM	Activity of PKA divided by its Michaelis constant	1 s-1	Miller et al., 2005
KM	The Michaelis constant of PP1	10 µM	0.4 to 20 µM (Zhabotinsky, 2000)
KH1	Hill constant of CaMKII (Ca2+ ) activation)	0.7 µM	(De Koninck and Schulman, 1998)
nH1	Hill constant of CaMKII (Ca2+ ) activation)	3	(Stemmer and Klee, 1994)
KH2	Hill constant of CaMKII (Ca2+ ) activation)	0.3 µM	(Stemmer and Klee, 1994)
nH2	Hill constant of CaMKII (Ca2+ ) activation)	3	(Stemmer and Klee, 1994)
k1	The catalytic constant of autophospho-rylation	1.5 s-1	(Hanson et al., 1994)
k2	The catalytic constant of autophospho-rylation	1 s-1	(Bradshaw et al., 2003; Ichikawa et al., 1996)
k3	The association rate constant of PP1.I1P complex	100 µM-1s-1	(Endo et al., 1996; Miller et al., 2005)
k4	The dissociation rate constant of PP1.I1P complex	0.1 s-1	(Endo et al., 1996; Miller et al., 2005)
${\mathrm{k}}_{\mathrm{x}}^{+}$	The rate of adding unphosphorylated subunit x	1 s-1 per NCaMKII	This paper
${\mathrm{k}}_{\mathrm{y}}^{+}$	The rate of adding phosphorylated sub- unit y	1 s-1 per NCaMKII	This paper
${\mathrm{k}}_{\mathrm{x}}^{-}$	The rate of losing unphosphorylated subunit x	0.1 s-1	This paper
${\mathrm{k}}_{\mathrm{y}}^{-}$	The rate of losing phosphorylated sub- unit y	0.1 s-1	This paper
vt	Turnover rate of CaMKII	30 h-1	(Ehlers, 2003; Miller et al., 2005)
DPP1	Diffusion coefficient of PP1	0.5 µm2 s−1	This paper and (Harvey et al., 2008)
Dsub	Diffusion coefficient of CaMKII subunits	10-5 – 10µm2 s−1	This paper