Figure 10:

Connectivity from VTA defined by “STIM A” (figure 8) projected on the right hemispheric surface as defined by various connectomes. Top row: Patient specific structural connectivity using DTI, Gibbs’ Tracking and GQI methods. Mid row: Connections defined by the structural Gibbsconnectome, HCP Adult Diffusion and PPMI PD connectomes. Bottom row: Functional connectivity between VTA and other brain regions as defined by normative GSP 1000 and PPMI 74 PD connectomes. This figure demonstrates a multitude of options to analyze VTA connectivity in Lead-DBS, but also highlights challenges of the process, since different methods/datasets yield different results.