Table 9:
Preprocessing strategies used to explain variance in 1.5T retrospective cohort.
| VTA strategy | MR volumes used |
Shown in fig. 11 |
Correlation (image metric vs. motor improvement) |
GLM (+ additional covariates) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Normalization strategy | R | p | RSME [%] | R2 | Overall p | Significant predictors (p < 0.05) | |||
| Binary VTA overlap | |||||||||
| Monospectral FSL FNIRT | T1 | Panel A | 0.38 | < 0.007 | 15.1 | 0.43 | < 0.005 | Sex | |
| Multispectral ANTs SyN | w/o subcortical refine | T1 & T2 | − | 0.46 | < 0.001 | 15.3 | 0.45 | < 0.005 | Sex |
| with subcortical refine | T1 & T2 | − | 0.49 | < 0.001 | 14.8 | 0.48 | < 0.005 | Sex, VTA overlap | |
| Multispectral SPM New Segment | T1 & T2 | − | 0.51 | < 10−4 | 14.7 | 0.49 | < 0.001 | Sex, VTA overlap | |
| Weighted E-field VTA / STN overlap | |||||||||
| Monospectral FSL FNIRT | T1 | − | 0.46 | < 0.001 | 15.1 | 0.46 | < 0.005 | Sex | |
| Multispectral ANTs SyN | w/o subcortical refine | T1 & T2 | − | 0.47 | < 0.001 | 15.3 | 0.46 | < 0.005 | Sex |
| with subcortical refine | T1 & T2 | Panel B | 0.52 | < 10−4 | 14.9 | 0.48 | < 0.005 | Sex, E-Field overlap | |
| Multispectral SPM New Segment | T1 & T2 | Panel C | 0.54 | < 10−4 | 14.5 | 0.51 | < 0.001 | Sex, E-Field overlap | |
| Weighted streamline counts to SMA | |||||||||
| Weighted streamline counts to SMA seeding from E-Field (based method one row above) | T1 & T2 | Panel D | 0.53 | < 10−4 | 14.8 | 0.49 | < 0.005 | Sex, Streamlines to SMA | |