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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: Cell Rep. 2018 Nov 13;25(7):1786–1799.e4. doi: 10.1016/j.celrep.2018.10.058

Figure 7. Structural and Functional Rearrangements of the RC in the Absence of COX7A2L.

Figure 7.

(A) Fully assembled CIII2 and CIV accumulate until they reach a threshold that ignites SC III2+IV and respirasome assembly at rates arbitrarily indicated by arrows. In the absence of COX7A2L, CIII2 levels are ~2–3-fold, SC III2+IV is not formed, and the assembly kinetics of CIII-containing SCs is slower.

(B) In physiological, nutritional, and environmental stress conditions, individual and simultaneous oxidation of NADH- and FAD-linked substrates is similar in WT and COX7A2L-KO cells. Mitochondrial CI, CIII2, and CIV are represented in blue, green, and red, respectively. COX7A2L is represented as a black stick.