Fig 1.

Somatic mutation and putative pathogenic germline mutant allele fractions (MAFs) for all 156 individuals with putative germline mutations arranged by lowest to highest somatic MAF. This included 169 samples in total; 144 individuals had one sample evaluated, and 12 had more than one sample evaluated (25 samples total; Appendix Tables A1 and A2). Putative germline mutations (pathogenic germline) had MAFs close to 50%, whereas somatic mutations had lower MAFs, as expected. Copy number variation corrections account for MAFs greater than 60%. Some samples did not have somatic mutations.