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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Curr Opin Immunol. 2018 Sep 22;55:22–30. doi: 10.1016/j.coi.2018.09.006

Figure 1: Autoimmune insulitis in the DORmO mouse model of T1D is associated with the progressive, sequential loss of local tissue barriers against autoimmunity.

Figure 1:

H&E staining of islets from DORmO mice at various ages and stages of progressive insulitis: (A) no infiltration (3–4 weeks of age), (B) peri-insulitis (4–5 weeks), (C) insulitis (8 weeks), and (D) islet destruction (12 weeks).