Table 2.
Multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of venous thromboembolism according to somatotype at age 10 in Nurses’ Health Study (1986–2014), Nurses’ Health Study II (1993–2015), and Health Professionals Follow-Up Study (1988–2012).
| Cases | Person-years | Multivariable-adjusted modela | Multivariable-adjusted model + BMIb | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Somatotype at Age 10 | ||||
| NHS | ||||
| 1 | 720 | 545,611 | 1.00 (Reference) | 1.00 (Reference) |
| 2 | 609 | 460,807 | 1.07 (0.96, 1.19) | 1.02 (0.92, 1.14) |
| 3 | 406 | 307,607 | 1.07 (0.94, 1.20) | 0.96 (0.85, 1.09) |
| 4 | 315 | 221,993 | 1.15 (1.00, 1.31) | 0.99 (0.86, 1.13) |
| >5 | 306 | 196,353 | 1.29 (1.13, 1.48) | 1.09 (0.95, 1.25) |
| p-trend | <0.01 | 0.53 | ||
| NHS II | ||||
| 1 | 328 | 352,569 | 1.00 (Reference) | 1.00 (Reference) |
| 2 | 499 | 579,711 | 0.97 (0.84, 1.11) | 0.89 (0.78, 1.03) |
| 3 | 453 | 430,130 | 1.15 (1.00, 1.33) | 0.93 (0.80, 1.07) |
| 4 | 323 | 298,815 | 1.13 (0.97, 1.32) | 0.83 (0.70, 0.97) |
| >5 | 334 | 227,285 | 1.47 (1.26, 1.71) | 1.02 (0.87, 1.20) |
| p-trend | <0.01 | 0.93 | ||
| HPFS | ||||
| 1 | 315 | 138,610 | 1.00 (Reference) | 1.00 (Reference) |
| 2 | 415 | 188,890 | 1.03 (0.88, 1.91) | 0.99 (0.85, 1.15) |
| 3 | 231 | 105,378 | 1.06 (0.89, 1.26) | 0.99 (0.83, 1.18) |
| 4 | 133 | 65,112 | 1.01 (0.82, 1.24) | 0.92 (0.74, 1.13) |
| >5 | 241 | 101,813 | 1.21 (1.02, 1.44) | 1.07 (0.90, 1.28) |
| p-trend | 0.05 | 0.68 |
Abbreviations: NHS, Nurses’ Health Study; NHS II, Nurses’ Health Study II; HPFS, Health Professionals Follow-Up Study; BMI, body mass index; HR, hazard ratio; CI, confidence interval.
Adjusted for age, physical activity, smoking, prevalent diabetes, prevalent hypertension, prevalent hypercholesterolemia, prevalent MI/angina, prevalent cancer, prevalent rheumatological disease, aspirin use, hormonal therapy use (NHS and NHS II only), oral contraceptive use (NHS II only)
Further adjustment for adult BMI