Table 4.

Multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of venous thromboembolism according to waist circumference in Nurses’ Health Study (1986–2014), Nurses’ Health Study II (1993–2015), and Health Professionals Follow-Up Study (1988–2012).

	Cases	Person-years	Multivariable-adjusted modela	Multivariable-adjusted model + BMIb
			HR (95% CI)	HR (95% CI)
Waist Circumference (cm)
NHS
<72	117	200,749	1.00 (Reference)	1.00 (Reference)
72 to <80	227	242,662	1.46 (1.16, 1.83)	1.43 (1.14, 1.80)
80 to <88	265	221,825	1.64 (1.31, 2.06)	1.53 (1.21, 1.94)
88 to <96	247	133,250	2.41 (1.91, 3.05)	2.08 (1.61, 2.70)
>96	318	142,933	2.77 (2.20, 3.49)	2.08 (1.57, 2.76)
p-trend			<0.01	<0.01
NHS II
<72	112	231,394	1.00 (Reference)	1.00 (Reference)
72 to <80	148	219,412	1.45 (1.13, 1.86)	1.42 (1.11, 1.83)
80 to <88	155	166,870	1.93 (1.50, 2.48)	1.80 (1.37, 2.36)
88 to <96	111	94,756	2.45 (1.86, 3.21)	2.07 (1.46, 2.88)
>96	194	119,464	3.11 (2.41. 4.02)	2.26 (1.58, 3.23)
p-trend			<0.01	<0.01
HPFS
<89	138	111,149	1.00 (Reference)	1.00 (Reference)
89 to <95	202	116,279	1.23 (0.98, 1.53)	1.18 (0.94, 1.47)
95 to <101	287	112,328	1.68 (1.36, 2.07)	1.54 (1.23, 1.93)
101 to <107	188	78,474	1.48 (1.18, 1.86)	1.31 (1.02, 1.69)
>107	253	62,980	2.30 (1.84, 2.87)	2.00 (1.53, 2.62)
p-trend			<0.01	<0.01

Abbreviations: NHS, Nurses’ Health Study; NHS II, Nurses’ Health Study II; HPFS, Health Professionals Follow-Up Study; BMI, body mass index; HR, hazard ratio; CI, confidence interval; cm, centimeter.

^aAdjusted for age, physical activity, smoking, prevalent diabetes, prevalent hypertension, prevalent hypercholesterolemia, prevalent MI/angina, prevalent cancer, prevalent rheumatological disease, aspirin use, hormonal therapy use (NHS and NHS II only), oral contraceptive use (NHS II only)

^bFurther adjustment for adult BMI